残余胆固醇与心血管、癌症死亡率的相关性:一项全国性队列研究  

Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort

作　　者：田原 武依 戚敏杰 宋莉娟 陈伯望 王椿淇 路甲鹏 杨阳 张小艳 崔建兰 许巍 杨皓 贺文彦 张岩 郑昕 张海波 郭远林 李希 Yuan Tian;Yi Wu;Minjie Qi;Lijuan Song;Bowang Chen;Chunqi Wang;Jiapeng Lu;Yang Yang;Xiaoyan Zhang;Jianlan Cui;Wei Xu;Hao Yang;Wenyan He;Yan Zhang;Xin Zheng;Haibo Zhang;Yuanlin Guo;Xi Li(National Clinical Research Center of Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450000,China;Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China;Shenzhen Center for Cardiovascular Diseases,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen 501800,China;Central China Sub-Center of the National Center for Cardiovascular Diseases,Zhengzhou 450000,China)

机构地区：[1]National Clinical Research Center of Cardiovascular Diseases,State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China [2]Henan Provincial Center for Disease Control and Prevention,Zhengzhou 450000,China [3]Department of Cardiology,Fuwai Hospital,National Center for Cardiovascular Disease,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China [4]Shenzhen Center for Cardiovascular Diseases,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen 501800,China [5]Central China Sub-Center of the National Center for Cardiovascular Diseases,Zhengzhou 450000,China

出　　处：《Science Bulletin》2024年第4期526-534,共9页科学通报（英文版）

基　　金：supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Science(2021-1-I2M-011);the National High-Level Hospital Clinical Research Funding(2022-GSP-GG-4);the Ministry of Finance of China and National Health Commission of China;the 111 Project from the Ministry of Education of China(B16005).

摘　　要：The health significance of triglyceride-rich lipoproteins,also known as remnant cholesterol,has been increasingly recognized.However,evidence of their associations with cause-specific mortality in the general population was previously insufficient.To explore these associations and their heterogeneities across subgroups,a prospective cohort study was conducted including 3,403,414 community-based participants from China HEART,an ongoing government-funded public health program throughout China,from November 2014 through December 2022.The study assessed mortality risk of all-cause mortality,cardiovascular disease(CVD)mortality(including mortality from ischemic heart diseases(IHD),ischemic stroke(IS),and hemorrhagic stroke(HS),separately),and cancer mortality(including lung cancer,stomach cancer,and liver cancer,separately).During the 4-year follow-up,23,646 individuals died from CVD(including 8807 from IHD,3067 from IS,and 5190 from HS),and 20,318 from cancer(including 6208 from lung cancer,3013 from liver cancer,and 2174 from stomach cancer).Compared with individuals with remnant cholesterol<17.9 mg/d L,multivariable-adjusted mortality hazard ratios(HRs)for individuals with remnant cholesterol≥27.7 mg/d L were 1.03(1.00–1.05)for all-cause mortality,1.17(1.12–1.21)for CVD(1.19(1.12–1.27)for IHD mortality,and 1.22(1.09–1.36)for IS mortality),and 0.90(0.87–0.94)for allcancer mortality(0.94(0.87–1.02)for lung cancer,0.59(0.53–0.66)for liver cancer,and 0.73(0.64–0.83)for stomach cancer).In summary,this study revealed a correlation between increased remnant cholesterol levels and an elevated risk of cardiovascular disease mortality,as well as a reduced risk of mortality for certain types of cancer.

关 键 词：Remnant cholesterol MORTALITY Cardiovascular disease CANCER 

分 类 号：R54[医药卫生—心血管疾病] R73-31[医药卫生—内科学]