Antibacterial mechanism with consequent cytotoxicity of different reinforcements in biodegradable magnesium and zinc alloys: A review  

作　　者：Chowdhury Ahmed Shahed Faiz Ahmad Ebru Günister Farhana Mohd Foudzi Saad Ali Khurshid Malik Wan Sharuzi Wan Harun 

机构地区：[1]Department of Mechanical Engineering,Universiti Teknologi PETRONAS(UTP),32610,Seri Iskandar,Perak,Malaysia [2]Faculty of Engineering and Natural Sciences,Department of Mechanical Engineering,Istanbul Health and Technology University,Istanbul,Turkey [3]Department of Mechanical and Manufacturing Engineering,Faculty of Engineering and Built Environment,Universiti Kebangsaan Malaysia,43600 UKM Bangi,Selangor,Malaysia [4]Faculty of Mechanical&Automotive Engineering Technology,Universiti Malaysia Pahang,26600 Pekan,Pahang,Malaysia

出　　处：《Journal of Magnesium and Alloys》2023年第9期3038-3058,共21页镁合金学报（英文）

基　　金：support by Universiti Teknologi PETRONAS (UTP),Malaysia,under Grant No.015LC0-336。

摘　　要：Benefits achieved by the biodegradable magnesium(Mg) and zinc(Zn) implants could be suppressed due to the invasion of infectious microbial, common bacteria, and fungi. Postoperative medications and the antibacterial properties of pure Mg and Zn are insufficient against biofilm and antibiotic-resistant bacteria, bringing osteomyelitis, necrosis, and even death. This study evaluates the antibacterial performance of biodegradable Mg and Zn alloys of different reinforcements, including silver(Ag), copper(Cu), lithium(Li), and gallium(Ga). Copper ions(Cu^(2+)) can eradicate biofilms and antibiotic-resistant bacteria by extracting electrons from the cellular structure. Silver ion(Ag^(+)) kills bacteria by creating bonds with the thiol group. Gallium ion(Ga^(3+)) inhibits ferric ion(Fe^(3+)) absorption, leading to nutrient deficiency and bacterial death. Nanoparticles and reactive oxygen species(ROS) can penetrate bacteria cell walls directly, develop bonds with receptors, and damage nucleotides. Antibacterial action depends on the alkali nature of metal ions and their degradation rate, which often causes cytotoxicity in living cells. Therefore, this review emphasizes the insight into degradation rate, antibacterial mechanism, and their consequent cytotoxicity and observes the correlation between antibacterial performance and oxidation number of metal ions.

关 键 词：Biodegradable materials Biomedical implants Antibacterial mechanism CYTOTOXICITY Reactive oxygen species 

分 类 号：TG146.22[一般工业技术—材料科学与工程] TG146.13[金属学及工艺—金属材料] R318.08[金属学及工艺—金属学]