The necessity of pretreatment with 0.1%pranoprofen for femtosecond-assisted cataract surgery:A single-center,randomized controlled trial  

作　　者：Zhao Geng Ling Gao Chongyi Li He Xiao Liqi Fan Pei Liu Juan Yu Rongdi Yuan Jian Ye 

机构地区：[1]Department of Ophthalmology,Daping Hospital,Army Medical University,Chongqing,China [2]Cancer Center,Daping Hospital,Army Medical University,Chongqing,China [3]Department of Ophthalmology,Xinqiao Hospital,Army Medical University,Chongqing,China

出　　处：《Advances in Ophthalmology Practice and Research》2023年第4期153-158,共6页眼科实践与研究新进展（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(grant number 81700824);the Social and Livelihood Issues of Chongqing(grant number 305-2769).

摘　　要：Purpose:To explore the effect of the variation of pupil diameter(PD)and intraocular pressure(IOP)induced by femtosecond laser treatment on the subsequent phacoemulsfication and intraocular lens implantation.And whether the application of 0.1%pranoprofen could significantly reduce the miosis and increased IOP caused by femtosecond laser treatment in femtosecond laser-assisted cataract surgery(FLACS).Methods:In this study,patients were pretreated with(trial group)or without(control group)topical 0.1%pranoprofen.The PD and IOP were measured at different time points within 30 min after the completion of the femtosecond laser treatment.Results:The comparisons of the two groups showed the PD of patients pretreated with 0.1%pranoprofen was significantly larger than that of the control only at 15 min after FLACS(P=0.046),and there was no significant difference in IOP at any time point(P>0.05).Neither the ratio of significant miosis(PD≤5 mm)nor intraocular hypertension(IOP≥30 mmHg)was significantly different between the control group(1.72%,6.67%)and the trial group(1%,4.17%)(P>0.05).Conclusions:The PD and IOP of patients undergoing FLACS showed fluctuations within a small range.The rates of significant miosis and intraocular hypertension are very low,it is safe for surgeons to complete the follow-up procedures within 30 min after femtosecond laser treatment.Pretreatment with 0.1%pranoprofen exerted a slight,albeit significant prophylactic effect preventing pupil miosis.However,it provided only a limited benefit in patients undergoing FLACS without other complications.

关 键 词：Pupil diameter Intraocular pressure FEMTOSECOND CATARACT 

分 类 号：R779.66[医药卫生—眼科]