慢性脑供血不足患者炎症因子、脑白质改变与认知功能障碍发生的相关性  

Correlation between inflammatory factors,white matter changes and the occurrence of cognitive dysfunction in patients with chronic cerebral circulation insufficiency

作　　者：钟华胜[1] 吴莉 危国星 熊国平[1] 赵欢田 ZHONG Huasheng;WU Li;WEI Guoxing;XIONG Guoping;ZHAO Huantian(Department of Neurology,the First People's Hospital of Fuzhou,Jiangxi Province,Fuzhou344000,China)

机构地区：[1]江西省抚州市第一人民医院神经内科,江西抚州344000

出　　处：《中国当代医药》2024年第5期64-67,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202312408)。

摘　　要：目的研究慢性脑供血不足(CCCI)患者炎症因子、脑白质改变与认知功能障碍发生的相关性。方法选取2022年6月至2023年2月在抚州市第一人民医院接受治疗的CCCI患者80例作为研究对象。采用简易精神状态评价量表(MMSE)为患者实施精神状态评估,并以27分作为临界点,总分<27分表示存在认知功能障碍,记为观察组(37例)。总分≥27分表示认知功能正常,记为对照组(43例)。比较两组蒙特利尔认知评估量表(MoCA)评分,血清C反应蛋白(CRP)、降钙素原(PCT)水平及脑白质改变(ARWMC)评分,分析观察组患者血清CRP、PCT水平及ARWMC评分与MoCA评分的相关性。结果观察组MoCA评分总分值低于对照组,差异有统计学意义(P<0.05)。观察组血清CRP、PCT水平及ARWMC评分均高于对照组,差异有统计学意义(P<0.05)。根据Pearson法分析相关性,观察组患者血清CRP、PCT水平及ARWMC评分与MoCA评分均呈负相关(r=0.651、0.708、0.649,P<0.05)。结论CCCI患者炎症因子、脑白质改变与其认知功能障碍发生均具有相关性,且主要表现为血清CRP、PCT水平及ARWMC评分与MoCA评分均呈负相关,值得关注。Objective To study the correlation between inflammatory factors,white matter changes and the occurrence of cognitive dysfunction in patients with chronic cerebral circulation insufficiency(CCCI).Methods A total of 80 patients with CCCI treated in the First People's Hospital of Fuzhou from June 2022 to February 2023 were selected as study objects.The patients'mental state was assessed by the mini-mental state examination(MMSE),and 27 score was taken as the critical point.The total score<27 indicated cognitive dysfunction and was recorded as the observation group(37 cases).The total score≥27 indicated normal cognitive function and was recorded as the control group(43 cases).The Montreal cognitive assessment scale(MoCA)score,serum C-reactive protein(CRP),procalcitonin(PCT)levels and age-related white matter change(ARWMC)score of the two groups were compared,and the correlation between serum CRP,PCT,ARWMC and MoCA score in the observation group were analyzed.Results The total MoCA score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The level of serum CRP,PCT and ARWMC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).According to Pearson method,serum CRP,PCT,ARWMC level and MoCA score were negative correlated in the observation group(r=0.651、0.708、0.649,P<0.05).Conclusion Inflammatory factors and white matter changes in CCCI patients are correlated with cognitive dysfunction,and the main manifestations are negative correlation between serum CRP,PCT,ARWMC score and MoCA score,which is worthy of attention.

关 键 词：慢性脑供血不足 炎症因子 脑白质改变 认知功能障碍 相关性 

分 类 号：R745.1[医药卫生—神经病学与精神病学]