眼部肿瘤术中冰冻切片病理诊断分析  

Pathological diagnosis of intraoperative frozen section of ocular tumor

作　　者：张萌萌 杜满 ZHANG Mengmeng;DU Man(Department of Ophtalmology,Jinan Huashi Eye Hospital,Huaxia Eye Hospital Group,Shandong Province,Jinan250011,China;Department of Pathology,Eye Hospital of Shandong First Medical University,Shandong Eye Hospital,Shandong Province,Jinan250021,China)

机构地区：[1]华厦眼科医院集团济南华视眼科医院眼科,山东济南250011 [2]山东第一医科大学附属眼科医院山东省眼科医院病理科,山东济南250021

出　　处：《中国当代医药》2024年第5期124-128,共5页China Modern Medicine

摘　　要：目的通过分析送检冰冻切片检查的眼部肿瘤特点,探究冰冻切片检查在眼部肿瘤诊疗中的应用价值,为临床诊断和治疗眼睑肿瘤提供参考依据。方法选取2015年10月至2023年4月在山东省眼科医院行眼部肿瘤切除治疗且行术中冰冻切片检查和石蜡切片病理检查的41例患者作为研究对象,分析患者的病理诊断结果和所有临床资料。结果41例患者中男18例,女23例;年龄32~85岁,平均(63.15±13.27)岁。恶性肿瘤患者年龄大于良性肿瘤患者,差异有统计学意义(P<0.05)。经术中冰冻切片病理诊断确诊34例,准确度为82.9%,其中完全符合19例(46.3%),基本符合15例(36.6%);延迟诊断7例,延迟诊断率为17.1%。本研究中诊断为眼部恶性肿瘤的有26例(63.4%),其中经冰冻切片确诊的有24例,恶性肿瘤中最常见的是基底细胞癌14例(53.8%),其次是皮脂腺癌8例(30.8%);诊断为眼部良性肿瘤的有15例(36.6%),其中经冰冻切片确诊的有10例,良性肿瘤中最常见的是炎性病变5例(33.3%),色素痣3例(20.0%)和真皮纤维组织瘤样增生2例(13.3%)。术中冰冻切片病理诊断平均完成时间为(29.54±8.39)min。结论术中冰冻切片病理诊断准确率相对较高且耗时短,可帮助临床医生术中迅速判断肿瘤性质,确定手术切缘是否残留肿瘤细胞,对手术切缘进行控制,值得在眼部肿瘤术中辅助诊断中推广应用。Objective By analyzing the characteristics of ocular tumors submitted for frozen section examination,the application value of frozen section examination in the diagnosis and treatment of ocular tumors was explored,providing a reference for clinical diagnosis and treatment of eyelid tumors.Methods From October 2015 to April 2023,41 patients who underwent ocular tumor resection in Shandong Eye Hospital and underwent intraoperative frozen section examination and paraffin section pathological examination were selected as the research objects.The pathological diagnosis results and all clinical data of the patients were analyzed.Results Among the 41 patients,18 were males and 23 were females.The average age was(63.15±13.27)years,ranging from 32 to 85 years.The age of malignant tumor patients was higher than that of benign tumor patients,and the difference was statistically significant(P<0.05).The accuracy of pathological diagnosis was 82.9%in 34 cases,of which 19 cases(46.3%)were completely consistent and 15 cases(36.6%)were basically consistent.The delayed diagnosis rate was 17.1%in 7 cases.In this study,26 cases(63.4%)were diagnosed as ocular malignant tumors,of which 24 cases were confirmed by frozen section.The most common malignant tumors were basal cell carcinoma in 14 cases(53.8%),followed by sebaceous adenocarcinoma in 8 cases(30.8%).15 cases(36.6%)were diagnosed as benign ocular tumors,of which 10 cases were confirmed by frozen section.The most common benign tumors were inflammatory lesions in 5 cases(33.3%),pigmented nevus in 3 cases(20.0%)and dermal fibromatoid hyperplasia in 2 cases(13.3%).The average completion time of pathological diagnosis in frozen section was(29.54±8.39)min.Conclusion The accuracy rate of intraoperative pathological diagnosis of frozen section is relatively high and the time is short,which can help clinicians quickly determine the nature of the tumor,determine whether the surgical margin has residual tumor cells,and control the surgical margin,which is worthy of promotion and applica

关 键 词：眼部肿瘤 病理诊断 冰冻切片 石蜡切片 

分 类 号：R739.7[医药卫生—肿瘤]