趋化因子CCL2与肺癌的因果关系:两样本孟德尔随机化研究  

The causal relationship between chemokine CCL2 and lung cancer:a two⁃sample Mendelian randomization study

作　　者：刘梓燊 郑瑛瑛 袁梦琪 张甘霖[1] 杨国旺[1] LIU Zishen;ZHENG Yingying;YUAN Mengqi;ZHANG Ganlin;YANG Guowang(Beijing Hospital of Tradi-tional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院,北京100010

出　　处：《实用医学杂志》2024年第4期532-536,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:82174453,82374538);北京市自然科学基金资助项目(编号:7222270)。

摘　　要：目的探究趋化因子CCL2(又称单核细胞趋化蛋白1,MCP-1)与肺癌(lung cancer)是否具有因果关系。方法从全基因组关联研究(GWAS)提取趋化因子CCL2和肺癌不同病理分型的遗传数据,使用逆方差加权分析(IVW)作为主要分析,另选用加权中位数法、简单模式法、MR-Egger回归法、加权模式法进行补充分析,并进行敏感性分析验证数据的可靠性。结果趋化因子CCL2对肺腺癌的IVW分析结果OR=1.065,95%CI(0.919~1.234),P=0.401。趋化因子CCL2对肺鳞状细胞癌的IVW分析结果OR=1.059,95%CI(0.931~1.205),P=0.381。趋化因子CCL2对小细胞肺癌的IVW分析结果OR=0.959,95%CI(0.760~1.208),P=0.720。结论趋化因子CCL2与肺癌没有直接因果关系。Objective To investigate whether chemokine CCL2(also known as monocyte chemotactic protein 1 or MCP⁃1)has a causal relationship with lung cancer.Methods Genetic data of chemokine CCL2 and different pathological subtypes of lung cancer were extracted from genome⁃wide association studies(GWAS),and inverse⁃variance weighted(IVW)analysis was used as main analysis,while weighted median,simple model,MR⁃Egger regression,and weighted model were chosen as supplementary analyses.Sensitivity analyses were performed to verify the reliability of the data.Results The result of IVW analysis on chemokine CCL2 to lung adenocarcinoma was OR=1.065,95%CI(0.919~1.234),P=0.401.The result of IVW analysis on chemokine CCL2 to squamous cell lung carcinoma was OR=1.059,95%CI(0.931~1.205),P=0.381.The result of IVW analysis on chemokine CCL2 to small cell lung carcinoma was OR=0.959,95%CI(0.760~1.208),P=0.720.Conclusions There is no direct causal relationship between chemokine CCL2 and lung cancer.

关 键 词：孟德尔随机化 单核细胞趋化因子 肺癌 因果关系 

分 类 号：R734.2[医药卫生—肿瘤]