双相情感障碍患者脑结构及脑血流灌注的MRI研究进展  

Advances in MRI studies of brain structure and cerebral blood perfusion in patients with bipolar disorder

作　　者：南霞 李汶玲 王琳 NAN Xia;LI Wenling;WANG Lin(The First Clinical Medical College of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃中医药大学附属医院放射科,兰州730000

出　　处：《实用医学杂志》2024年第4期580-584,共5页The Journal of Practical Medicine

基　　金：甘肃省科技计划项目(编号:18JR2FA001)。

摘　　要：双相情感障碍(BD)是一类常见精神心理疾病,其高发病率、高致残率、高死亡率引起广泛关注。在临床实践中,BD的初次准确诊断率较低,容易被误诊为单相抑郁症。许多神经影像学研究表明,BD患者部分脑区的皮层厚度、灰质、白质以及功能活动发生改变,但其特异的神经影像学指标尚未明确,对于BD发病的特殊病理生理机制也尚未完全阐明。因此,本文梳理了近年来关于BD患者研究脑皮层结构及血流灌注的方法进行综述,以期望后期进行更深入的研究。Bipolar disorder(BD)is a class of common psychiatric disorders,and its high morbidity,disability,and mortality have attracted widespread attention.However,in clinical practice,the initial accurate diagnosis rate of BD is low and easily misdiagnosed as monophasic depression.Many neuroimaging studies have shown that cortical thickness,gray matter,white matter,and functional activities are altered in some brain regions of BD patients.However,their specific neuroimaging indexes have not been clarified,and the specific pathophysi⁃ological mechanisms for the onset of BD have not been fully elucidated.Therefore,in this paper,we combed through the recent years of BD patients to study the cortical structure and perfusion of the brain to review the methods in anticipation of more in-depth research at a later stage.

关 键 词：双相情感障碍 MRI 基于体素形态学 基于表面形态学 扩散张量成像 动脉自选标记 SPECT PET-CT 

分 类 号：R749.41[医药卫生—神经病学与精神病学]