循环肿瘤DNA检测在人乳头瘤病毒相关性宫颈癌中的应用与展望  

Application and prospects of ctDNA detection in HPV associated cervical cancer

作　　者：江宝妮 张美琴 杨露 陈致远 韩娜娜 JIANG Baoni;ZHANG Meiqin;YANG Lu;CHEN Zhiyuan;HAN Na′na(Obstetrics and Gynecology Medical Center of the Zhujiang Hospital of Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学珠江医院妇产医学中心,广州510280

出　　处：《实用医学杂志》2024年第2期129-132,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金青年科学基金项目(编号:82001501)。

摘　　要：循环肿瘤DNA(circulating tumor DNA,ctDNA)是直接来源于肿瘤的无细胞状态DNA,其常携带全面的肿瘤基因信息;研究发现ctDNA的检测可在肿瘤的早期诊断、靶向治疗以及预测复发中发挥作用;人乳头瘤病毒(human papilloma virus,HPV)相关性妇科恶性肿瘤主要包括大部分宫颈癌、部分外阴癌及阴道癌,高危型HPV长期感染以及与细胞基因组的整合为这些癌肿重要的致病原因,研究发现利用ctDNA检测技术动态检测HPV-ctDNA的变化则可以为这些肿瘤的临床管理以及预后提供有价值的信息。因此,HPV-ctDNA有望成为HPV相关肿瘤的重要生物标志物。Circulating tumor DNA(ctDNA)is a kind of cell-free DNA derived from tumors,which carries comprehensive tumor genetic information;Recent studies have found that ctDNA detection can play a role in the early diagnosis,targeted therapy,and prediction of recurrence in tumors.Human papillomavirus(HPV)-associated gynecological malignancies include most cervical cancer,some vulvar cancer,and vaginal cancer.High-risk HPV long-term infection and integration with cell genome are important causes of these cancers.Studies found that the use of ctDNA detection technology to dynamically monitor changes in HPV-ctDNA can provide valuable information for the clinical management and prognosis of these cancers.Thus,HPV-ctDNA is expected to become an biomarker for HPV-associated tumors.

关 键 词：HPV-ctDNA 人乳头瘤病毒 宫颈癌 妇科恶性肿瘤 外阴癌 阴道癌 

分 类 号：R737.33[医药卫生—肿瘤]