头皮针联合康复训练对急性脑梗死患者血清MCP-1、ET、sICAM-1水平及神经功能康复的影响  

Effect of scalp acupuncture combined with rehabilitation training on serum MCP-1,ET,sICAM-1 content and nerve function rehabilitation in patients

作　　者：肖畅 杨丹 韦天未 张泓[1] XIAO Chang;YANG Dan;WEI Tianwei;ZHANG Hong(College of Acupuncture and Massage,Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;不详)

机构地区：[1]湖南中医药大学针灸推拿学院,湖南长沙410208 [2]贵州中医药大学第二附属医院针灸康复科,贵州贵阳550003

出　　处：《中华全科医学》2024年第2期301-303,320,共4页Chinese Journal of General Practice

基　　金：国家自然科学基金项目(82274666);贵州省中医药管理局中医药课题(QZYY-2020-066)。

摘　　要：目的观察头皮针治疗联合康复训练对脑梗死急性期患者血清中单核细胞趋化因子-1(MCP-1)、内皮素(ET)、可溶性细胞间黏附分子-1(sICAM-1)的水平及神经功能缺损评分(NIHSS)、Fugl-Meyer运动功能评分(FMA)、改良Barthel指数(MBI)评分的影响,为临床应用提供一定的科学依据。方法受试对象为2021年6月—2023年8月在贵州中医药大学第二附属医院就诊的脑梗死急性期患者78例,采用随机数字表法分为对照组和观察组,每组各39例,2组均给予相同的基础治疗,对照组加用一般康复训练,观察组在对照组基础上联合使用头皮针治疗,均持续治疗2周,比较2组患者干预前后血清MCP-1、ET、sICAM-1水平及NIHSS、FMA、MBI评分的变化。结果2组患者治疗前血清MCP-1、ET、sICAM-1水平及NIHSS、FMA、MBI评分差异均无统计学意义(P>0.05);治疗2周后,2组MCP-1、ET、sICAM-1水平均明显下降(P<0.05),且观察组均低于对照组(P<0.05);观察组NIHSS评分[(5.18±1.68)分]低于对照组[(7.47±2.25)分,P<0.001],FMA评分[(47.59±14.62)分]高于对照组[(34.69±13.34)分,P<0.001],MBI评分[(72.28±18.88)分]高于对照组[(62.59±17.53)分,P<0.001]。结论头皮针治疗联合康复训练可显著降低急性脑梗死患者血清中MCP-1、ET、sICAM-1水平,明显改善神经缺损症状,提高患者运动功能和生存质量,促进神经功能的康复。Objective To explore the effects of scalp acupuncture combined with rehabilitation training on the levels of monocyte chemoattractant protein-1(MCP-1),endothelin(ET),soluble intercellular adhesion molecule-1(sICAM-1)in the serum of patients with acute cerebral infarction,as well as the National Institute of Health stroke scale(NIHSS),Fugl-Meyer assessment(FMA),and modified Barthel index(MBI)score,and provide a scientific basis for clinical application.Methods The subjects were 78 patients with acute cerebral infarction who were treated at the Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from June 2021 to August 2023.They were randomly divided into a control group and an observation group using a random number table method,with 39 patients in each group,and all subjects received the same basic treatment.The control group received general rehabilitation training,while the observation group received scalp acupuncture treatment in combination with the control group for 2 weeks.The serum MCP-1 levels of the two groups before and after intervention,changes in ET,sICAM-1 levels,and NIHSS,FMA,and MBI scores were compared.Results Before treatment,there was no statistically significant difference in the levels of serum MCP-1,ET,sICAM-1,and NIHSS,FMA,and MBI scores between the two groups of patients(P>0.05).After 2 weeks of treatment,the levels of MCP-1,ET,and sICAM-1 in the serum of both groups significantly decreased(P<0.05),and the observation group was lower than the control group(P<0.05);The NIHSS score of the observation group[(5.18±1.68)points]was lower than that of the control group[(7.47±2.25)points,P<0.001],the FMA score[(47.59±14.62)points]was higher than that of the control group[(34.69±13.34)points,P<0.001],and the MBI score[(72.28±18.88)points]was higher than that of the control group[(62.59±17.53)points,P<0.001].Conclusion Scalp acupuncture combined with rehabilitation training can significantly reduce the content of MCP-1,ET and sICAM-1 in serum of patients with acut

关 键 词：头皮针 康复训练 急性脑梗死 血清单核细胞趋化因子-1 可溶性细胞间黏附分子-1 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R245.3[医药卫生—临床医学]