多烯磷脂酰胆碱注射液对自身免疫性肝炎患者肝功能指标的影响  

Effect of polyene phosphatidylcholine injection on liver function indexes in patients with autoimmune hepatitis

作　　者：陈凯 孟祥林 Chen Kai;Meng Xianglin(Department of Pharmacy,Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou,Henan 450007,China)

机构地区：[1]郑州市中医院药学部,河南郑州450007

出　　处：《中国药物与临床》2023年第10期665-669,共5页Chinese Remedies & Clinics

摘　　要：目的研究多烯磷脂酰胆碱注射液对自身免疫性肝炎患者肝功能、肝纤维化、血清趋化因子指标的影响,以期为临床治疗自身免疫性肝炎提供借鉴。方法将146例郑州市中医院于2022年3月至2023年2月收治的自身免疫性肝炎患者按治疗方法分为对照组(73例)与研究组(73例),对照组行复方甘草酸苷口服治疗,研究组行复方甘草酸苷口服的同时,加用多烯磷脂酰胆碱注射液静脉滴注治疗,治疗周期为4周。比较2组临床效果,治疗前后谷氨酰转移酶、白蛋白、天冬氨酸转氨酶、Ⅳ型胶原、透明质酸、Ⅲ型前胶原、层黏蛋白、甘胆酸、血清趋化因子(CF-9、CF-8、CF-2)水平、肝硬度值及生活质量。结果相对于对照组的临床总有效率(86.3%),研究组(95.9%)较高(P<0.05)。治疗后2组与治疗前比白蛋白水平均升高,研究组相较于对照组升高,谷氨酰转移酶、天冬氨酸转氨酶、Ⅳ型胶原、透明质酸、Ⅲ型前胶原、层黏蛋白、甘胆酸、血清CF-9、CF-8、CF-2水平及肝硬度值均降低,研究组相较于对照组降低(P<0.05)。2组治疗期间腹泻、头痛、恶心总发生率差异无统计学意义(P>0.05)。结论多烯磷脂酰胆碱注射液治疗自身免疫性肝炎患者可提高临床疗效,改善患者肝功能与肝纤维化,改善肝脏炎症反应,减少肝细胞损伤,安全性良好,可为临床治疗自身免疫性肝炎提供参考依据。Objective To study the effects of polyene phosphatidylcholine injection on liver function,liver fibrosis and serum chemokines indexes in patients with autoimmune hepatitis,in order to provide a reference basis for clinical treatment of autoimmune hepatitis.Methods A total of 146 patients with autoimmune hepatitis admitted to ZhengZhou Hospital of Traditional Chinese Medicine from March 2022 to February 2023 were divided into a control group(73 cases)and a experimental group(73 cases)according to the methods of treatment.The control group received oral treatment with compound glycyrrhizin,while the experimental group received oral treatment of compound glycyrrhizin,plus intravenous treatment with polyene phosphatidylcholine injection,the treatment period was 4 weeks.The clinical effects,levels of serum chemokines(CF-9,CF-8,CF-2),liver hardness and quality of life before and after treatment were compared between the two groups.Results Compared with the control group(86.3%),the total clinical effective rate of the research group(95.9%)was higher(P<0.05).Compared with the control group,the level of specific albumin in the research group was increased after treatment,while the level of glutamyl transpeptide,glutamic oxalacetic transaminase,type IV collagen,hyaluronic acid,typeⅢprocollagen,laminin,glycholic acid,serum CF-9,CF-8,CF-2 and liver hardness were decreased in the research group compared with the control group(P<0.05).The total incidence of diarrhea,headache and nausea during treatment was statistically insignificant in both groups(P>0.05).Conclusion Polyene phosphatidylcholine injection in the treatment of patients with autoimmune hepatitis can improve the clinical efficacy,improve the liver function and liver fibrosis of patients,improve the inflammation response of the liver,reduce liver cell damage,and have good safety,which can provide reference for clinical treatment of autoimmune hepatitis.

关 键 词：多烯磷脂酰胆碱注射液 肝炎 自身免疫性 肝功能 

分 类 号：R575.1[医药卫生—消化系统]