经典名方甘草附子汤治疗骨关节病的研究进展  

Treatment of Bone and Joint Diseases with Gancao Fuzitang:A Review

作　　者：刘宾[1] 程传浩[1] 张延武[1] 常征辉[1] 段涛[1] LIU Bin;CHENG Chuanhao;ZHANG Yanwu;CHANG Zhenghui;DUAN Tao(College of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学中医学院,郑州450046

出　　处：《中国实验方剂学杂志》2024年第5期282-288,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省中医药文化与管理研究项目(TCM2020025)。

摘　　要：甘草附子汤来源于《伤寒杂病论》,主治“骨节烦疼”“不得屈伸”,具有补益脾肾,祛湿化浊之效,故临床广泛应用于各种骨关节疾病的治疗。该文对甘草附子汤治疗骨关节疾病的临床研究和作用机制方面进行了综述。研究发现,甘草附子汤在治疗风湿性关节炎、类风湿、强直性脊柱炎、痛风、椎间盘突出等骨关节疾病等方面有较好的疗效,其作用机制可能与调控炎症因子水平、抗氧化、调控炎症及凋亡细胞相关通道的蛋白质表达、改善骨质疏松、缓解相关症状等有关。该研究可为进一步深化甘草附子汤防治骨关节疾病的研究提供参考。Gancao Fuzitang originates from the Treatise on Febrile Diseases and Miscellaneous Diseases(《伤寒杂病论》)and is mainly used to treat pain in the bones and joints and symptoms such as no flexion or extension.It has the effect of tonifying the spleen and kidney and removing dampness and turbidity,so it is widely used in the clinical treatment of various bone and joint diseases.This article reviewed the clinical research and mechanism of Gancao Fuzitang in the treatment of bone and joint diseases.The research has found that this prescription has good efficacy in treating bone and joint diseases such as rheumatoid arthritis,rheumatoid arthritis,ankylosing spondylitis,gout,and intervertebral disc herniation.Its mechanism of action may be related to regulating the level of inflammatory factors,antioxidation,and the protein expression of inflammatory and apoptotic cell-related pathways,improving bone and joint diseases,and alleviating related symptoms.This study can provide a reference for further deepening the research on the prevention and treatment of bone and joint diseases with Gancao Fuzitang.

关 键 词：骨关节病 甘草附子汤 作用机制 临床应用 综述 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R2-031R289R274R68