Prenatal cadmium exposure impairs neural tube closure via inducing excessive apoptosis in neuroepithelium  

作　　者：Shiyong Zhu Xuenan Li Xueyan Dai Jinlong Li 

机构地区：[1]College of Veterinary Medicine,Northeast Agricultural University,Harbin 150030,China [2]Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment,Northeast Agricultural University,Harbin 150030,China [3]Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine,Northeast Agricultural University,Harbin 150030,China

出　　处：《Journal of Environmental Sciences》2024年第4期572-584,共13页环境科学学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.32172932);the Key Program of Natural Science Foundation of Heilongjiang Province of China(No.ZD2021C003);the China Agriculture Research System of MOF and MARA(No.CARS-35);the Distinguished Professor of Longjiang Scholars Support Project(No.T201908);the Heilongjiang Touyan Innovation Team Program。

摘　　要：Birth defects have become a public health concern.The hazardous environmental factors exposure to embryos could increase the risk of birth defects.Cadmium,a toxic environmental factor,can cross the placental barrier during pregnancy.Pregnant woman may be subjected to cadmium before taking precautionary protective actions.However,the link between birth defects and cadmium remains obscure.Cadmium exposure can induce excessive apoptosis in neuroepithelium during embryonic development progresses.Cadmium exposure activated the p53 via enhancing the adenosine 5‘-monophosphate(AMP)-activated protein kinase(AMPK)and reactive oxygen species'(ROS)level.And cadmium decreases the level of Paired box 3(Pax3)and murine double minute 2(Mdm2),disrupting the process of p53 ubiquitylation.And p53 accumulation induced excessive apoptosis in neuroepithelium during embryonic development progresses.Excessive apoptosis led to the failure of neural tube closure.The study emphasizes that environmental materials may increase the health risk for embryos.Cadmium caused the failure of neural tube closure during early embryotic day.Pregnant women may be exposed by cadmium before taking precautionary protective actions,because of cadmium concentration-containing foods and environmental tobacco smoking.This suggests that prenatal cadmium exposure is a threatening risk factor for birth defects.

关 键 词：Cadmium Neural tube closure Excessive apoptosis p53 EMBRYOGENESIS 

分 类 号：R994.6[医药卫生—毒理学] X503.1[医药卫生—药学]