平消胶囊联合R-CHOP方案治疗老年B细胞非霍奇金淋巴瘤患者的疗效分析  

Effect analysis of Pingxiao capsule combined with R-CHOP regimen in the treatment of elderly patients with B-cell non-Hodgkin lymphoma

作　　者：王聪 申娅媚 赵海涛 李倩 韩雪萍 张玉霞 杨子龙 张花花 赵丽 WANG Cong;SHEN Yamei;ZHAO Haitao;LI Qian;HAN Xueping;ZHANG Yuxia;YANG Zilong;ZHANG Huahua;ZHAO Li(Department of Hematology,Gansu Wuwei Tumour Hospital,Gansu Wuwei 733000,China.)

机构地区：[1]甘肃省武威肿瘤医院血液科,甘肃武威733000

出　　处：《现代肿瘤医学》2024年第6期1106-1109,共4页Journal of Modern Oncology

摘　　要：目的:探讨平消胶囊联合常规化疗方案(R-CHOP)对老年B细胞非霍奇金淋巴瘤(B-cell non-Hodgkin lymphoma,B-NHL)患者的临床疗效。方法:选取2019年01月至2023年01月本院收治的80例B-NHL患者(>60岁),随机分为对照组和实验组,每组40例。对照组患者采用R-CHOP方案化疗,实验组患者采用平消胶囊联合R-CHOP方案治疗,对比分析两组患者的疗效差异。结果:实验组患者的ORR、CR率分别为90.00%、40.00%,高于对照组(P<0.05)。实验组患者CD3+、CD4+、CD4+/CD8+、CD56+细胞比例均高于对照组,CD8+细胞比例低于对照组(P<0.05)。实验组不良反应与对照组相比无明显统计学差异。结论:老年B-NHL患者的临床治疗中应用平消胶囊联合R-CHOP方案有助于提升疗效,改善免疫功能,不良反应较轻,安全性好。Objective:To investigate the clinical effect of the Pingxiao capsule combined with conventional chemotherapy(R-CHOP)on elderly patients with B-cell non-Hodgkin lymphoma(B-NHL).Methods:A total of 80 patients(>60 years old)with B-NHL admitted to our hospital from January 2019 to January 2023 were randomly divided into a control group and an experimental group,with 40 cases in each group.The control group was treated with R-CHOP chemotherapy,while the experimental group was treated with Pingxiao capsule combined with R-CHOP.The difference in efficacy between the two groups was compared and analyzed.Results:The ORR and CR rates of the experimental group were 90.00%and 40.00%,respectively,higher than those of the control group(P<0.05).The proportion of CD3+,CD4+,CD4+/CD8+,and CD56+cells in the experimental group was higher than that in the control group,and the proportion of CD8+cells was lower than that in the control group(P<0.05).There was no significant difference in adverse reactions between the experimental group and the control group.Conclusion:In the clinical treatment of elderly patients with B-NHL,the application of Pingxiao capsule combined with R-CHOP regimen is helpful to improve the efficacy and immune function,with mild adverse reactions and good safety.

关 键 词：平消胶囊 B细胞非霍奇金淋巴瘤 老年患者 疗效 

分 类 号：R733.4[医药卫生—肿瘤]