左乙拉西坦治疗儿童良性癫痫伴中央颞区棘波的临床效果  

Clinical Effect of Levetiracetam in Treatment of Benign Childhood Epilepsy with Centrotemporal Spikes

作　　者：陈元璐 Chen Yuanlu(Chenzhou First People's Hospital,Chenzhou 423000,Hunan Province,China)

机构地区：[1]郴州市第一人民医院,湖南郴州423000

出　　处：《中国社区医师》2024年第1期48-50,共3页Chinese Community Doctors

基　　金：郴州市技术创新引导项目(编号:lcyl2021042)。

摘　　要：目的:探讨左乙拉西坦治疗儿童良性癫痫伴中央颞区棘波(BECT)的临床效果。方法:选取2020年4月—2021年9月郴州市第一人民医院儿童神经内科收治的BECT患儿40例作为研究对象,根据随机数字表法分为两组,各20例。对照组采用丙戊酸钠治疗,观察组采用左乙拉西坦治疗。比较两组治疗效果。结果:两组治疗总有效率比较,差异无统计学意义(P>0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P=0.018)。两组癫痫样放电总控制率比较,差异无统计学意义(P>0.05)。治疗前,两组言语智商、操作智商、全量表智商评分比较,差异无统计学意义(P>0.05);治疗后,两组言语智商、操作智商、全量表智商评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:左乙拉西坦与丙戊酸钠治疗儿童BECT的临床效果均较为理想,均能改善患儿癫痫样放电情况,但左乙西坦在提高患儿认知功能及用药安全性方面效果更优。Objective:To explore the clinical effect of levetiracetam in treatment of benign childhood epilepsy with centrotemporal spikes(BECT).Methods:A total of 40 BECT children in the Department of Children's Neurology of Chenzhou First People's Hospital from April 2020 to September 2021 were selected as the study subjects.They were divided into two groups according to random number table method,with 20 cases in each group.The control group was treated with sodium valproate,and the observation group was treated with levetiracetam.The therapeutic effect in two groups was compared.Results:There was no significant difference in the total effective rate between the two groups(P>0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.018).There was no significant difference in the total control rate of epileptiform discharge between the two groups(P>0.05).Before treatment,there was no significant difference in the scores of verbal IQ,operative IQ and full-scale IQ between the two groups(P>0.05);After treatment,the scores of verbal IQ,operative IQ and full-scale IQ in the two groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion:The clinical effects of levetiracetam and sodium valproate in the treatment of BECT children are satisfactory,and both drugs can improve the epileptiform discharge of children,but levetiracetam has a better effect in improving children's cognitive function and drug safety.

关 键 词：儿童 良性癫痫 中央颞区棘波 丙戊酸钠 左乙拉西坦 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]