Legionella pneumophila-mediated host posttranslational modifications  

作　　者：Yi Yang Ligang Mei Jing Chen Xiaorong Chen Zhuolin Wang Lu Liu Aimin Yang 

机构地区：[1]School of Life Sciences,Chongqing University,Chongqing 401331,China

出　　处：《Journal of Molecular Cell Biology》2023年第5期7-20,共14页分子细胞生物学报（英文版）

基　　金：funded by the National Natural Science Foundation of China(32170185,22011530161,31801166,and 91854101);the Natural Science Foundation of Chongqing,China(cstc2021jcyj-msxmX0030 and CSTB2022NSCQ-MSX0463);the Venture Innovation Support Program for Chongqing Overseas Returnees(cx2022066);the Fundamental Research Funds for the Central Universities(2022CDJYGRH-002);the National Training Program of Innovation and Entrepreneurship for Undergraduates(202210611088).

摘　　要：Legionella pneumophila is a Gram-negative bacterium ubiquitously present in freshwater environments and causes a serious type of pneumonia called Legionnaires’disease.During infections,L.pneumophila releases over 300 effector proteins into host cells through an Icm/Dot type IV secretion system to manipulate the host defense system for survival within the host.Notably,certain effector proteins mediate posttranslational modifications(PTMs),serving as useful approaches exploited by L.pneumophila to modify host proteins.Some effectors catalyze the addition of host protein PTMs,while others mediate the removal of PTMs from host proteins.In this review,we summarize L.pneumophila effector-mediated PTMs of host proteins,including phosphorylation,ubiquitination,glycosylation,AMPylation,phosphocholination,methylation,and ADP-ribosylation,as well as dephosphorylation,deubiquitination,deAMPylation,deADP-ribosylation,dephosphocholination,and delipidation.We describe their molecular mechanisms and biological functions in the regulation of bacterial growth and Legionella-containing vacuole biosynthesis and in the disruption of host immune and defense machinery.

关 键 词：Legionella pneumophila bacterial effector posttranslational modification host-pathogen interaction Legionellacontaining vacuole PATHOGENESIS host defense system 

分 类 号：Q942[生物学—植物学]