盐酸考来维仑的合成工艺研究  

Study on synthetic process of colesevelam hydrochloride

作　　者：吴辉[1] 张红贞[1] 彭佳佳 乔苗 郑忠辉[1] WU Hui;ZHANG Hong-zhen;PENG Jia-jia;QIAO Miao;ZHENG Zhong-hui(Shandong Xinhua Pharmaceutical Co.,Ltd.,Zibo 255086,China)

机构地区：[1]山东新华制药股份有限公司,山东淄博255086

出　　处：《中国药物化学杂志》2023年第12期910-913,共4页Chinese Journal of Medicinal Chemistry

摘　　要：目的优化盐酸考来维仑的合成工艺。方法以烯丙基胺盐酸盐为起始原料,经聚合、交联、烷基化3步反应制得盐酸考来维仑。结果与结论目标化合物盐酸考来维仑结构经固体核磁共振碳谱、红外光谱、元素分析、粉末X-射线衍射法确证。优化后的合成工艺反应条件温和、操作简便、成本低、产品质量稳定,适合工业化生产。The synthesis process of colesevelam hydrochloride was optimized.With allylamine hydrochloride as the starting material,colesevelam hydrochloride was prepared through polymerization,cross-linking,and alkylation.The structure of colesevelam hydrochloride was confirmed by solid-state ^(13)C-NMR,IR,elemental analysis and powder X-ray diffraction.This improved process has several advantages including mild conditions,simple operations,low cost,stable product quality,and is suitable for industrial production.

关 键 词：盐酸考来维仑 化学合成 原发性高脂血症 2型糖尿病 

分 类 号：R914[医药卫生—药物化学]