NEU%、CRP及IL-6水平对白血病合并肺部感染的诊断价值探讨  

Diagnostic value of NEU%,CRP and IL-6 levels in leukemia complicated with pulmonary infection

作　　者：赵鑫[1] 郑辉[1] 刘燕子 Zhao Xin;Zheng Hui;Liu Yan-zi(Department of Clinical Laboratory,The Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,Henan,China)

机构地区：[1]新乡医学院第三附属医院检验科,河南新乡453003

出　　处：《四川生理科学杂志》2024年第2期250-252,共3页Sichuan Journal of Physiological Sciences

基　　金：新乡市科技发展计划项目(编号:GG2021037)。

摘　　要：目的:研究联合中性粒细胞百分比(Percentage of neutrophils,NEU%)、C-反应蛋白(C-reactive protein,CRP)及白介素-6(Interleukin-6,IL-6)在白血病合并肺部感染中的诊断价值。方法:选取2019年1月到2023年1月在我院收治的81例白血病患者作为研究对象。根据感染标准分为未感染组(36例)和感染组(45例)。感染组患者进一步根据感染程度分级,分为轻度感染组(32例)与重度感染组(13例)。对比未感染组和感染组外周血中NEU%、CRP、IL-6水平;对比轻度感染组与重度感染组外周血中NEU%、CRP、IL-6水平;探讨NEU%、CRP、IL-6水平单独及联合检测对白血病合并感染的诊断效能。结果:对比两组外周血中NEU%、CRP、IL-6水平,感染组3个指标均高于未感染组(P<0.05)。轻度感染组中NEU%、CPR、IL-6指标水平均低于重度感染组(P<0.05)。NEU%特异度为50.31%,灵敏度为80.20%,准确度为69.83%,CRP特异度为50.00%,灵敏度为88.37%,准确度为75.69%,IL-6特异度为40.36%,灵敏度为92.32%,准确度为72.32%,三项联合特异度为67.32%,灵敏度为96.51%,准确度为86.62%(P<0.05)。结论:白血病合并肺部感染中联合NEU%、CRP及IL-6水平明显升高,且三者联合对白血病合并肺部感染诊断价值高。Objective:To investigate the diagnostic value of combined Percentage of neutrophils(NEU%),C-reactive protein(CRP)and Interleukin-6(IL-6)in leukemia complicated with pulmonary infection.Methods:81 patients with leukemia admitted to our hospital from January 2019 to January 2023 were selected as the study objects.According to the infection criteria,the patients were divided into uninfected group(36 cases)and infected group(45 cases).According to the degree of infection,patients in the infected group were further divided into mild infection group(32 cases)and severe infection group(13 cases).The levels of NEU%,CRP and IL-6 in peripheral blood of uninfected and infected groups were compared.The levels of NEU%,CRP and IL-6 in peripheral blood were compared between the mild infection group and the severe infection group.Objective To explore the diagnostic efficacy of NEU%,CRP and IL-6 alone and combined detection in leukemia coinfection.Results:The levels of NEU%,CRP and IL-6 in peripheral blood of the two groups were compared,and the three indexes in the infected group were higher than those in the uninfected group(P<0.05).The levels of NEU%,CPR and IL-6 in mild infection group were lower than those in severe infection group(P<0.05).The specificity of NEU%was 50.31%,the sensitivity 80.20%,and the accuracy 69.83%;the specificity of CRP was 50.00%,the sensitivity 88.37%,and the accuracy 75.69%;the specificity of IL-6 was 40.36%,the sensitivity 92.32%,and the accuracy 72.32%.The combined specificity,sensitivity and accuracy were 67.32%,96.51%and 86.62%(P<0.05).Conclusion:The levels of NEU%,CRP and IL-6 in leukemia combined with lung infection are significantly increased,and the combined levels of the three are valuable in the diagnosis of leukemia combined with lung infection.

关 键 词：中性粒细胞百分比 C-反应蛋白 白介素-6 白血病 肺部感染 

分 类 号：R733.7[医药卫生—肿瘤]