尤瑞克林对椎基底动脉系统脑梗死患者神经功能、脑循环血流动力学及血管内皮功能的影响  

Effects of urinary kallidinogenase on nerve function,cerebral circulation hemodynamics,and vascular endothelial function in patients with Vertebrobasilar system cerebral infarction

作　　者：郭晓洁 李浩 刘营营 李瑞红 章晓富 Guo Xiao-jie;Li Hao;Liu Ying-ying;Li Rui-hong;Zhang Xiao-fu(Department of Neurology,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China;Department of Vascular Surgery,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属郑州中心医院神经内科,河南郑州450000 [2]郑州大学附属郑州中心医院血管外科,河南郑州450000

出　　处：《四川生理科学杂志》2024年第2期279-281,287,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:分析椎基底动脉系统脑梗死患者应用尤瑞克林治疗对神经功能、脑循环血流动力学及血管内皮功能的影响。方法:选取我院2021年1月至2022年8月期间收治的108例椎基底动脉系统脑梗死患者作为研究对象,采用随机数字表法分组(n=54)。对照组静脉滴注盐酸罂粟碱30 mg bid治疗,联合组增加静脉滴注尤瑞克林0.15 PNA单位qd治疗。治疗2 w后,采用美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、高级中枢损伤严重程度(Advanced central injury severity,MESSS)评分测定神经功能;采用彩色超声诊断系统测定大脑中动脉血流量(Blood flow,Q)、血流速度(Blood flow velocity,V),外周血管阻力(Peripheral vascular resistance,R)等脑循环血流动力学指标;采用酶联免疫吸附法测定血管内皮生长因子(Vascular endothelial growth factor,VEGF),钙黏蛋白(Vascular endothelial growth factor,VE-cadherin)、单核细胞趋化因子1(Monocyte chemokine 1,MCP-1)、基质金属蛋白酶-9(Matrix metalloproteinase-9,MMP-9)等血管内皮功能指标,并记录不良反应。结果:联合组患者NIHSS评分、MESSS评分均低于对照组(P<0.05);联合组患者大脑中动脉Q、V均高于对照组,R低于对照组(P<0.05);联合组患者VEGF水平高于对照组,VE-cadherin、MCP-1、MMP-9水平均低于对照组(P<0.05);两组患者不良反应发生率比较(P>0.05)。结论:尤瑞克林能够有效提高椎基底动脉系统脑梗死患者神经功能,改善脑血液循环状态血管内皮功能,且安全性高。Objective:To analyze the effects of urinary kallidinogenase therapy on nerve function,cerebral circulation hemodynamics,and vascular endothelial function in patients with vertebrobasilar system cerebral infarction.Methods:A total of 108 patients with cerebral infarction of the vertebrobasilar system admitted to our hospital from January 2021 to August 2022 were selected as the control group and the combination group by random number table method(n=54).The control group was given an intravenous infusion of papaverine hydrochloride 30 mg bid,and the combination group was given an intravenous infusion of urinary kallidinogenase 0.15 PNA unit qd.After 2 weeks of treatment,the National Institutes of Health Stroke Scale(NIHSS)score,advanced central injury severity,and nerve function were measured by the MESSS score.Blood flow(Q),blood flow velocity(V),and peripheral vascular resistance(R)in the brain were measured by the color ultrasonic diagnostic system,and the levels of vascular endothelial growth factor(VEGF),vascular endothelial growth factor(VE-cadherin),monocyte chemokine 1(MCP-1),and matrix metalloproteinase-9(MMP-9)were measured by enzyme-linked immunoadsorption assay.Also,adverse reactions were recorded.Results:NIHSS score and MESSS score of the combination group were lower than those of the control group(P<0.05).Middle cerebral artery Q and V in the combination group were higher than those in the control group,while R was lower than that in the control group(P<0.05).The levels of VEGF in the combination group were higher than those in the control group,and the levels of VE-cadherin,MCP-1,and MMP-9 were lower than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Urinary kallidinogenase can effectively improve nerve function and vascular endothelial function of cerebral blood circulation in patients with vertebrobasilar artery system infarction,with high safety.

关 键 词：尤瑞克林 椎基底动脉系统脑梗死 神经功能 脑循环血流动力学 血管内皮功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]