儿童结膜囊肿11例临床病理分析  

Clinical pathological analysis of 11 children with conjunctival cyst

作　　者：李强 周春菊[3] 苏学刚 崔燕辉[2] 白大勇[2] Li Qiang;Zhou Chunju;Su Xuegang;Cui Yanhui;Bai Dayong(Beijing Children's Hospital Shunyi Maternal and Child Health Hospital Ophthalmology 101321,China;Beijing Children's Hospital,Capital Medical University,100045,China)

机构地区：[1]顺义妇幼保健院眼科,北京101321 [2]首都医科大学附属北京儿童医院眼科,100045 [3]首都医科大学附属北京儿童医院病理科,100045

出　　处：《临床眼科杂志》2024年第1期57-61,共5页Journal of Clinical Ophthalmology

基　　金：北京市属医院科研培育计划项目(PX2019047)。

摘　　要：目的探讨儿童结膜囊肿患者的组织病理学特点并探讨发病原因。方法对11例(12只眼)儿童结膜囊肿手术的患者进行回顾性分析,主要包括年龄、性别、眼部疾病,发病部位、组织病理学特点。结果11例眼部结膜囊肿患者年龄(79.18±22.77)个月(2岁7个月至10岁7个月),男性8例,女性3例,10例有眼外肌手术史,1例为先天性囊肿。10例行HE染色,PAS染色及免疫组化染色(MUC5AC、CK、D2-40),1例行透射电镜检查。HE染色可见囊肿内壁为扁平上皮或者复层柱状上皮组织,2例与肌肉组织相连。PAS染色,3例弱阳性,2例阳性。免疫组化染色:MUC5AC染色5例弱阳性,1例阳性;CK染色及D2-40染色,10均为强阳性。1例可见淋巴管D2-40染色阳性。结论儿童结膜囊肿内壁细胞以复层柱状上皮多见,含有少量非典型杯状细胞,与球结膜上皮有相似性,囊肿内淋巴管不多见。囊内液的具体来源尚需进一步的研究才能确定。Objective To study the histopathological characteristics of children with conjunctival cysts and the causes.Methods A retrospective analysis was performed on 11 children with conjunctival cyst who had surgery,whose age,gender,eye diseases,disease sites,and histopathological characteristics were collected.Results Eleven patients with conjunctival cysts(12 eyes),average age of(79.18±22.77)months.There were 8 males and 3 females,10 had a his⁃tory of extraocular muscle surgery,and 1 was a congenital cyst.Ten patients underwent HE staining,PAS staining and im⁃munohistochemical staining(MUC5AC,CK,D2-40),and one patient underwent transmission electron microscopy.HE staining showed that the inner wall of the cyst was flat epithelium or stratified epithelial tissue,and 2 cases were connected with muscle tissue.PAS staining was weakly positive in 3 cases and positive in 2 cases.Immunohistochemical staining:MUC5AC staining was weakly positive in 5 cases,and positive in 1 case;CK staining and D2-40 staining were 10,all were strongly positive.Lymphatic vessels with D2-40 staining was found in 1 case.Conclusions The inner wall cells of conjunc⁃tival cysts in children are more common in stratified columnar epithelium,which contain a small number of atypical goblet cells.They are similar to bulbar conjunctival epithelium,and the lymphatic vessels in cysts are rare.The specific source of the cyst fluid needs further research to determine。

关 键 词：结膜囊肿 儿童 病理 免疫组化 

分 类 号：R777.3[医药卫生—眼科]