Metal, iodine and oxidant-free electrosynthesis of substituted indoles from 1-(2-aminophenyl)alcohols  

作　　者：Chengcheng Yuan Xiangxing Huang Yi Lu Zheng Fang Chengkou Liu Beining Chen Kai Guo 

机构地区：[1]College of Biotechnology and Pharmaceutical Engineering,Nanjing Tech University,Nanjing 211816,China [2]Department of Chemistry,University of Sheffield,Sheffield S37HF,UK [3]State Key Laboratory of Materials-Oriented Chemical Engineering,Nanjing Tech University,Nanjing 211816,China

出　　处：《Green Synthesis and Catalysis》2023年第4期311-315,共5页绿色合成与催化（英文）

基　　金：The research was supported by the Natural Science Foundation of Jiangsu Province,Frontier Project(No.BK20212003);National Science Foundation of China(No.22008118).

摘　　要：A green and straightforward electrosynthesis of substituted indoles has been developed through dehydration and intramolecular dehydrogenative C–N bond-forming radical cross-coupling from 1-(2-aminophenyl)alcohols under metal,iodine and oxidant-free conditions.This electrochemical indole synthesis strategy has an excellent functional group,water and air tolerance.And,a possible cyclization process was proposed based on the radicaltrapping,intermediate verification,cyclic voltammetry,EPR and control experiments.

关 键 词：ELECTROSYNTHESIS METAL Iodine and oxidant-free C-N coupling INDOLES N-centered radicals 

分 类 号：O643.36[理学—物理化学]