Diastereo-selective synthesis of CF_(3)-substituted epoxide via in situ generated trifluoroethylideneiodonium ylide  

作　　者：Chenxin Ge Chao Chen 

机构地区：[1]Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education),Department of Chemistry,Tsinghua University,Beijing 100084,China [2]State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Green Synthesis and Catalysis》2023年第4期334-337,共4页绿色合成与催化（英文）

基　　金：This work was supported by the National Key Research and Development Program of China(No.2016YFB0401400);the National Natural Science Foundation of China(Nos.21871158 and 21672120);the Fok Ying Tong Education Foundation of China(No.151014).

摘　　要：The first example for the generation of 2,2,2-trifluoroethylidene ylide from corresponding iodonium salt is reported,which has been successfully applied in the epoxidation of aldehydes,achieving the corresponding tri-fluoromethylated epoxides in high yields and diastereo-selectivities.

关 键 词：TRIFLUOROMETHYL EPOXIDATION EPOXIDES Iodonium ylide Trifluoroethylidenation 

分 类 号：O64[理学—物理化学]