Spirooxindoles:Recent report of green synthesis approach  

作　　者：Agus Rimus Liandi Antonius Herry Cahyana Diva Naufal Alfariza Rahma Nuraini Renita Wulan Sari Tio Putra Wendari 

机构地区：[1]Department of Chemistry,Faculty of Science and Technology,Universitas Islam Negeri Syarif Hidayatullah Jakarta,Tangerang Selatan 15412,Indonesia [2]Department of Chemistry,Faculty of Mathematics and Natural Sciences,Universitas Indonesia,Depok 16424,Indonesia [3]Department of Chemistry,Faculty of Mathematics and Natural Sciences,Universitas Andalas,Padang 25163,Indonesia

出　　处：《Green Synthesis and Catalysis》2024年第1期1-13,共13页绿色合成与催化（英文）

基　　金：The authors gratefully acknowledge financial support from the Universitas Islam Negeri Syarif Hidayatullah Jakarta through the grant of BOPTN 2023[Contract number:UN.01/KPA/189/2023].

摘　　要：Spirooxindole is a compound with a unique framework and broad bioactivities in medicine.In this study,we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused on green synthesis.Synthesis of spirooxindoles is mainly carried out through multicomponent reactions combined with various green approaches such as the use of heterogeneous catalysts(nano-sized,magnetic,metal-complex,and metal-organic framework catalysts),deep eutectic solvent,solvent-free reactions,catalyst-free reactions,as well as the use of ultrasonic and microwaves irradiation.The green method is carried out in addition to obtaining high yields,it also offers reductions in the use of hazardous chemicals,energy use,purification processes,and waste generation.As a result,green synthesis methods in the synthesis of spirooxindole derivatives are more environmentally friendly.

关 键 词：SPIROOXINDOLES Green synthesis CATALYSIS NANOPARTICLE Ultrasonic irradiation 

分 类 号：O62[理学—有机化学]