络病理论指导恶性肿瘤癌因性疲乏理论探讨  

Theoretical Exploration of Cancer-related Fatigue in Malignant Tumors Guided by Luobing Theory

作　　者：尹玉洁 常丽萍[1,2,3] 魏聪 YIN Yujie;CHANG Liping;WEI Cong(National Key Laboratory for Innovation and Transformation of Luobing Theory,Shijiazhuang 050035,China;Key Laboratory of National Administration of Traditional Chinese Medicine(Cardiovascular and Cerebrovascular Luobing),Hebei Yiling Institute of Medicines,Shijiazhuang 050035,China;WU Yiling Famous Old Chinese Medicine Expert Inheritance Studio,Hebei Yiling Hospital,Shijiazhuang 050090,China)

机构地区：[1]络病理论创新转化全国重点实验室,石家庄050035 [2]河北以岭医药研究院,国家中医药管理局重点研究室(心脑血管络病),石家庄050035 [3]河北以岭医院,吴以岭名老中医药专家传承工作室,石家庄050090

出　　处：《中国实验方剂学杂志》2024年第6期211-217,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河北省络病重点实验室建设项目(20567627H);石家庄市复方中药新药技术创新中心绩效后补助项目(237790639A)。

摘　　要：癌因性疲乏患者易伴有厌食、减重、腹胀等症状或体征,严重降低生存质量,成为影响恶性肿瘤患者生存率的独立危险因素,亟需寻找有效的治疗策略及药物。既往基于络病理论指导提出“改善证候——肿瘤治疗新策略”学术观点,笔者以气络学说核心理论“承制调平”为指导,提出恶性肿瘤癌因性疲乏“脾肾两虚,瘀毒内阻”中医病机及“健脾益肾、化瘀解毒”治法,研制的代表药物养正消积胶囊不仅对实体瘤有良好的治疗作用,在治疗癌因性疲乏方面也显示出良好优势,有助于恢复恶性肿瘤患者“荷瘤生存”自稳平衡状态,为癌因性疲乏临床治疗提供新的药物选择。Patients with cancer-related fatigue are prone to symptoms and signs such as anorexia,weight loss,and abdominal distension,which seriously reduces the quality of life and becomes an independent risk factor affecting the survival rate of patients with malignant tumors.Therefore,it is urgent to find effective treatment strategies and drugs.In the past,the academic viewpoint of improving syndromes—a new strategy for tumor treatment was proposed based on the guidance of the Luobing theory.Based on this,this article proposes the pathogenesis of cancer-related fatigue is characterized by spleen and kidney deficiency,stasis and toxin internal obstruction,as well as the treatment method of strengthening the spleen and tonifying the kidney,resolving blood stasis and detoxification guided by the core theory of the Qiluo doctrine of Chengzhi Tiaoping.The representative drug Yangzheng Xiaoji capsules has been developed,not only has good therapeutic effect on solid tumors,but also shows good advantages in treating cancer-related fatigue,which can help to restore the homeostasis of tumor bearing survival in patients with malignant tumors and provide new drug choices for the clinical treatment of cancer-related fatigue.

关 键 词：络病理论 恶性肿瘤 癌因性疲乏(CRF) 承制调平 养正消积胶囊 中医药(TCM) 人用经验 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学] R273R73