全球疫苗研发现状和展望  

Progress and prospect of global vaccine research and development

作　　者：马磊[1] 杨昭庆[1] 王佑春 MA Lei;YANG Zhaoqing;WANG Youchun(Institute of Medical Biology,Chinese Academy of Medical Sciences,Kunming 650118,China)

机构地区：[1]中国医学科学院医学生物学研究所,昆明650118

出　　处：《中国药科大学学报》2024年第1期115-126,共12页Journal of China Pharmaceutical University

基　　金：中国医学科学院医学与健康科技创新工程项目(2022-I2M-3-001)。

摘　　要：频繁暴发的新发突发传染病已成为影响人类公共卫生及健康的重要危险因素,目前接种疫苗依然是应对传染病最关键的手段。新型冠状病毒感染(COVID-19)疫情以来,无论是创新型疫苗基础技术还是疫苗研发策略均取得了革命性进展,以m RNA技术为代表的第三代疫苗技术逐渐成为一种新兴的疫苗研发方式。本文对近年来的不同疫苗技术特点进行全面梳理,综述了基于不同技术平台的重点疫苗产品的最新研究进展,并展望了未来疫苗研发策略,为疫苗研发工作提供经验和借鉴。The emerging infectious diseases have become an important risk factor affecting human public health.Vaccination remains the most critical approach to the prevention and control of such diseases.Since the outbreak of the COVID-19 epidemic,lots of transformational basic innovative vaccine technologies and strategies have been developed.The third-generation vaccine technology represented by mRNA vaccine has gradually become a new approach to the research and development of vaccines.This paper introduces the characteristics of different vaccine technologies in recent years,and summarizes the latest research progress in current vaccine products based on different platforms,so as to provide experience and reference for future research and development of vaccines.

关 键 词：疫苗研发 疫苗技术平台 研究策略 重点疫苗产品 

分 类 号：R186[医药卫生—流行病学]