中药联合化疗对比单纯化疗治疗70岁以上老年肿瘤患者的不良反应观察  

Clinical observation of the adverse effects of Chinese medicine combined with chemotherapy compared with chemotherapy alone in the treatment of elderly tumor patients aged 70 years and older

作　　者：朱园 潘玉真[2] 李夏平[2] ZHU Yuan;PAN Yu-zhen;LI Xia-ping(Liaoning University of Traditional Chinese Medicine Shenyang,Shenyang 110847,China;不详)

机构地区：[1]辽宁中医药大学,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《中国处方药》2024年第2期153-156,共4页Journal of China Prescription Drug

摘　　要：目的对比中药联合化疗与单纯化疗治疗70岁以上老年恶性肿瘤患者产生的不良反应情况。方法通过回顾性同期队列研究,将2022年1月1日~12月31日在辽宁中医药大学附属医院肿瘤科住院的70岁以上接受化疗的恶性肿瘤患者64例,根据患者在化疗期间是否口服中药汤剂分为中药联合化疗组(32例)与单纯化疗组(32例),单纯化疗组仅采用西医化学药物治疗,中药联合化疗组在西药化疗的基础上配合中药治疗。对比观察两组患者治疗后的不良反应发生情况、后续化疗接受率以及卡氏功能状态(KPS)评分下降情况。结果中药联合化疗组不良反应发生率,Ⅲ、Ⅳ级不良反应包括骨髓抑制、胃肠道反应、肝功能损害、手足综合征发生率均显著低于单纯化疗组,中药联合化疗组后续化疗接受率优于单纯化疗组(90.63%vs.68.75%);两组患者用药后KPS评分均有所下降,但中药联合组下降情况优于化疗组。结论70岁以上老年肿瘤患者应用中药联合化疗对比单纯化疗后期化疗接受率较好,中药联合化疗可改善患者KPS评分下降情况,具有更少的不良反应,且不良反应的发生程度较轻。Objective To compare the adverse reactions of traditional Chinese medicine combined with chemotherapy and chemotherapy alone in the treatment of elderly patients with malignant tumors aged 70 years and older.Methods Based on a retrospective cohort study,64 patients aged 70 years and older who received chemotherapy in the Department of Oncology,Shu Hospital,Liaoning University of Traditional Chinese Medicine from January 1 to December 31,2022 were divided into traditional Chinese medicine combined with chemotherapy group(32 cases)and simple chemotherapy group(32 cases)according to whether they took oral traditional Chinese medicine decoction during chemotherapy.The simple chemotherapy group was treated with western chemical drugs only,and the traditional Chinese medicine combined chemotherapy group was treated with traditional Chinese medicine on the basis of western medicine chemotherapy.The incidence of adverse reactions,subsequent chemotherapy acceptance rate and the decline of KPS score after treatment were compared between the two groups.Results The incidence of adverse reactions,gradeⅢandⅣadverse reactions including bone marrow suppression,gastrointestinal reactions,liver function damage and hand-foot syndrome in the traditional Chinese medicine combined with chemotherapy group were significantly lower than those in the simple chemotherapy group,and the acceptance rate of subsequent chemotherapy in the traditional Chinese medicine combined with chemotherapy group was better than that in the simple chemotherapy group(90.63%vs.68.75%).The KPS scores of the two groups decreased after treatment,but the decline of the combination group was better than that of the chemotherapy group.Conclusion The acceptance rate of traditional Chinese medicine combined with chemotherapy is better than that of simple chemotherapy in elderly cancer patients aged 70 years and older.Traditional Chinese medicine combined with chemotherapy can improve the decline of KPS score,and has fewer adverse reactions,and the occurrence of ad

关 键 词：化疗 中药 不良反应 老年人 

分 类 号：R730.5[医药卫生—肿瘤]