MicroRNAs-微生物互作调控机体脂肪代谢研究进展  

MicroRNA-microbiota interaction regulates host lipid metabolism

作　　者：胡竑 贺芳 邓志颖 周锡红[2] 印遇龙[1,2] HU Hong;HE Fang;DENG ZhiYing;ZHOU XiHong;YIN YuLong(College of Animal Science and Technology,Hunan Agricultural University,Changsha 410128,China;Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha 410125,China)

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128 [2]中国科学院亚热带农业生态研究所,动物营养生理与代谢过程湖南省重点实验室,长沙410125

出　　处：《中国科学：生命科学》2024年第2期300-307,共8页Scientia Sinica(Vitae)

基　　金：国家重点研发计划(批准号:2022YFD1301500)资助。

摘　　要：微生物和microRNAs均参与机体脂肪酸吸收、转运和从头合成,以及脂肪动员和储存等代谢过程的调节.宿主分泌的microRNAs可通过调控微生物生长和代谢影响脂肪代谢.微生物一方面可影响宿主microRNAs分泌,另一方面其自身也可直接分泌microRNAs,并调节宿主的代谢功能.本文综述了microRNAs和微生物对机体脂肪代谢的影响和调控机制,重点探讨了microRNAs和微生物互作调控脂肪代谢的研究进展和作用机制,以期为精准靶向预防或治疗脂肪代谢紊乱相关疾病提供新的思路和依据.Intestinal microbes and microRNAs are both involved in the regulation of fatty acid absorption, transportation and de novo synthesis,lipid catabolism and storage. MicroRNAs derived from the host can regulate lipid metabolism via regulating specific microbe growthand metabolism. Microbes can either affect host microRNA expression or secreted microRNAs that target host genes and regulate themetabolic function of the host. In this review, we summarized the effects of intestinal microbes and microRNAs on host lipidmetabolism and the mechanisms involved. Furthermore, we highlight recent progress about the involvement of microRNAmicrobiota axis in the regulation of host lipid metabolism and their possible roles in the prevention and treatment of diseases causedby lipid metabolic disorders.

关 键 词：微生物 MICRORNA 脂肪代谢 胞外囊泡 

分 类 号：S852[农业科学—基础兽医学]