CXCL5在食管鳞状细胞癌组织中的表达及与临床特征及预后的关系  

Expression of CXCL5 in esophageal squamous cell carcinoma and its relationship with clinical features and prognosis

作　　者：黄丛改 刘清 郑树涛 刘涛[2] 谭依依 彭天元 陈娇 杨志惠 罗星 卢晓梅 Huang Conggai;Liu Qing;Zheng Shutao;Liu Tao;Tan Yiyi;Peng Tianyuan;Chen Jiao;Yang Zhihui;Luo Xing;Lu Xiaomei(State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Clinical Medical Research Institute,First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang Uygur Autonomous Region 830054,China;State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Department of Clinical Laboratory,First Affiliated Hospital of Xinjiang Medical University,Urumqi Xinjiang Uygur Autonomous Region 830054,China;Department of Pathology,Affiliated Hospital of Southwest Medical University,Luzhou Sichuan 646000,China)

机构地区：[1]新疆医科大学第一附属医院临床医学研究院,省部共建中亚高发病成因与防治国家重点实验室,新疆乌鲁木齐830054 [2]新疆医科大学第一附属医院医学检验中心,省部共建中亚高发病成因与防治国家重点实验室,新疆乌鲁木齐830054 [3]西南医科大学附属医院病理科,四川泸州646000

出　　处：《中国医刊》2024年第3期289-292,共4页Chinese Journal of Medicine

基　　金：省部共建中亚高发病成因与防治国家重点实验室开放课题面上项目(SKL-HIDCA-2022-14);省部共建中亚高发病成因与防治国家重点实验室食管癌专项(SKL-HIDCA-2020-JZ2);新疆维吾尔自治区“天山英才”培养计划科技创新领军人才项目(2022TSYCLJ0031);新疆维吾尔自治区自然科学基金-重点项目(2022D01D69)。

摘　　要：目的探讨C-X-C趋化因子5(CXCL5)在食管鳞状细胞癌(ESCC)组织中的表达及与临床特征及预后的关系。方法选取2020年1月至2021年12月于西南医科大学附属医院确诊的ESCC患者74例,采用免疫组化经典EnVision法检测经手术切除的ESCC组织和癌旁正常食管组织中CXCL5表达的差异,分析ESCC组织中CXCL5表达与临床病理特征的关系。结果CXCL5在ESCC组织中的表达水平(85.1%)显著高于癌旁正常食管组织(43.2%),差异有统计学意义(P<0.05)。ESCC组织中CXCL5表达水平与患者性别、年龄、肿瘤直径及神经侵犯均无关(P>0.05),而与肿瘤部位、病理分化程度、浸润深度、脉管瘤栓及淋巴结转移有关(P<0.05)。生物信息分析显示CXCL5高表达与ESCC的预后不良相关(P<0.05)。结论ESCC组织中CXCL5表达上调,CXCL5高表达与ESCC转移和预后不良相关。Objective The aim of this experiment is to investigate the expression and clinical significance of CXCL5 in ESCC.Method A total of 74 patients with ESCC diagnosed in the Affiliated Hospital of Southwest Medical University from January 2020 to December 2021 were selected.The difference of CXCL5 expression in the surgically resected ESCC tissues and adjacent normal esophageal tissues was detected by the immunohistochemical method,and the relationship between CXCL5 expression in ESCC tissues and clinicopathological characteristics was analyzed.Result The expression level of CXCL5 in ESCC tissues(85.1%)was significantly higher than that in adjacent normal esophageal tissues(43.2%),the difference was statistically significant(P<0.05).The expression level of CXCL5 in ESCC tissues was not correlated with gender,age,tumor diameter and nerve invasion(P>0.05),but was correlated with tumor location,pathological differentiation,depth of invasion,presence of vasculature embolus and lymph node metastasis(P<0.05).Bioinformatics analysis showed that high expression of CXCL5 was associated with poor prognosis of ESCC(P<0.05).Conclusion CXCL5 expression is upregulated in ESCC tissue,and high expression of CXCL5 is associated with metastasis and poor prognosis of patients.

关 键 词：C-X-C趋化因子5 食管鳞状细胞癌 临床意义 病理特征 

分 类 号：R735.1[医药卫生—肿瘤]