帕金森病患者出现冻结步态的危险因素分析  

Risk factors of freezing of gait in patients with Parkinson’s disease

作　　者：周知[1] 于洪伟[2] 焦劲松[1] 谢晟[2] 金淼[1] Zhou Zhi;Yu Hongwei;Jiao Jinsong;Xie Sheng;Jin Miao(Department of Neurology,China-Japan Friendship Hospital,Beijing 100029,China;Department of Radiology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院神经内科,北京100029 [2]中日友好医院放射诊断科,北京100029

出　　处：《中国医刊》2024年第3期309-313,共5页Chinese Journal of Medicine

基　　金：国家自然科学基金青年科学基金项目(82001360)。

摘　　要：目的探讨帕金森病(PD)患者出现冻结步态(FOG)的危险因素。方法选取2019年7月至2022年7月中日友好医院收治的52例PD患者为研究对象,根据是否合并FOG将研究对象分为FOG组(合并FOG,14例)和非FOG组(未合并FOG,38例)。比较分析非FOG组与FOG组患者的临床特征与影像学特征。比较分析非FOG组与FOG组患者的基底前脑功能连接。采用多因素logistic回归方法分析PD患者出现FOG的独立影响因素。结果FOG组患者的国际运动障碍学会统一帕金森病评定量表Ⅱ(MDS-UPDRSⅡ)评分高于非FOG组,差异有统计学意义(P<0.05),且Meynert基底核(Ch4)与双侧中扣带回、中央前回及辅助运动区的功能连接低于非FOG组。多因素logistic回归分析结果显示,MDS-UPDRSⅡ评分、Ch4功能连接是PD患者出现FOG的独立影响因素(P<0.05)。结论MDS-UPDRSⅡ评分升高、Ch4功能连接减弱为PD患者出现FOG的独立影响因素。Objective To investigate the risk factors of freezing of gait(FOG)in patients with Parkinson’s disease(PD).Method 52 PD patients admitted to China-Japan Friendship Hospital from July 2019 to July 2022 were selected as the research objects,and the research objects were divided into FOG group(with FOG,14 cases)and non-FOG group(without FOG,38 cases)according to whether with FOG.The clinical and imaging characteristics between non-FOG group and FOG group were compared and analyzed.The functional connections of basal forebrain were compared between non-FOG group and FOG group.Multivariate logistic regression method was used to analyze the independent influencing factors of FOG in PD patients.Result The MDS-UPDRSⅡscore in FOG group were higher than that in non-FOG group,with statistical significance(P<0.05)and the functional connections between Ch4 and bilateral middle cingulate gyrus,anterior central gyrus and auxiliar motor area were lower than those in non-FOG group.Multivariate logistic regression analysis showed that MDS-UPDRSⅡscore and Ch4 functional connection were independent influencing factors for FOG in PD patients(P<0.05).Conclusion Increased MDS-UPDRSⅡscore and decreased Ch4 functional connectivity were independent influencing factors for FOG in PD patients.

关 键 词：帕金森病 冻结步态 功能连接 危险因素 

分 类 号：R742.5[医药卫生—神经病学与精神病学]