口腔黏膜微核细胞计数及血清、唾液中CYFRA21-1水平与口腔上皮癌变进程的相关性研究  

Correlation Between Oral Mucosal Micronucleus Cell Count,Serum and SalivaCYFRA21-1 Levels and Oral Epithelial Carcinogenesis

作　　者：武宝峰 李宏[1] 孙吏聪 WU Baofeng;LI Hong;SUN LIcong(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471000)

机构地区：[1]河南科技大学第一附属医院,471000

出　　处：《实用癌症杂志》2024年第3期434-437,共4页The Practical Journal of Cancer

摘　　要：目的 探讨口腔黏膜微核细胞计数及血清、唾液中细胞角蛋白19片段(Cytokeratin-19-fragment, CYFRA21-1)水平与口腔上皮癌变进程的相关性。方法 对口腔疾病患者102例进行回归性分析,包括舌白斑57例(白斑组),口腔鳞状细胞癌45例(鳞癌组),另选同期检查口腔黏膜正常人员44例(正常组),对比各组人员的口腔黏膜微核细胞计数及血清、唾液中CYFRA21-1水平,分析各指标与口腔上皮癌变进程之间的关系。结果 三组的口腔黏膜微核细胞计数及血清、唾液CYFRA21-1表达水平:鳞癌组>白斑组>正常组,三组对比差异具有统计学意义(P<0.05);组间两两对比差异具有统计学意义(P<0.05)。鳞癌患者中晚期组的口腔黏膜微核细胞计数及血清、唾液CYFRA21-1表达水平均高于早期组,两组对比差异具有统计学意义(P<0.05)。根据单因素及多因素统计分析得,分化程度、淋巴结转移情况、口腔黏膜微核细胞计数、血清CYFRA21-1、唾液CYFRA21-1均为口腔鳞状细胞癌的癌症进程独立危险因素(P<0.05)。口腔黏膜微核细胞计数、血清CYFRA21-1、唾液CYFRA21-1单项检测的敏感度分别为84.0%、72.0%、64.0%,特异度为78.9%、68.4%、73.7%;联合检测的敏感度和特异度分别为88.0%、84.2%,其中联合检测的敏感度和特异度最高,对早期鳞癌和癌前病变的诊断效能最好。结论 口腔黏膜微核细胞计数及血清、唾液CYFRA21-1与口腔鳞癌的疾病进程存在密切联系,可以帮助预测诊断早期口腔鳞癌及癌前病变。Objective To investigate the correlation between the number of micronucleus cells in oral mucosa,the level of keratin-19 fragment(CYFRA21-1)in serum and saliva and the progression of oral epithelial carcinogenesis.Methods A regression analysis was conducted on 102 patients with oral diseases,including 57 cases of tongue leukoplakia(leukoplakia group)and 45 cases of oral squamous cell carcinoma(squamous cell carcinoma group).Another 44 individuals with normal oral mucosa were selected for the same period examination(normal group),and the oral mucosal micronucleus cell count and CYFRA21-1 levels in serum and saliva of each group were compared.The relationship between each indicator and the progression of oral epithelial cancer was analyzed.Results Oral mucosal micronucleus cell count and serum and saliva CYFRA21-1 expression levels in 3 groups:squamous cell carcinoma grou P>leukoplakia grou P>normal group,and the difference among the 3 groups was statistically significant(P<0.05);the difference between the each 2 groups was statistically significant(P<0.05).The micronucleus cell count of oral mucosa and the expression levels of CYFRA21-1 in serum and saliva in the advanced group of squamous cell carcinoma patients were higher than those in the early group,and the difference between the 2 groups was statistically significant(P<0.05).According to univariate and multivariate statistical analysis,differentiation,lymph node metastasis,oral mucosal micronucleus cell count,serum CYFRA21-1,and salivary CYFRA21-1 were all independent risk factors for cancer progression in oral squamous cell carcinoma(P<0.05).The sensitivity of single detection of oral mucosal micronucleus cell count,serum CYFRA21-1,and saliva CYFRA21-1 was 84.0%,72.0%,and 64.0%,respectively,and the specificity was 78.9%,68.4%,and 73.7%;the sensitivity and specificity of combined detection were 88.0%and 84.2%,respectively,with the highest sensitivity and specificity of combined detection and the best diagnostic efficacy for early squamous cell carcinoma and

关 键 词：口腔上皮癌变 黏膜 微核细胞计数 细胞角蛋白19片段 

分 类 号：R739.85[医药卫生—肿瘤]