刚毛黑孢壳菌感染致真菌性角膜炎1例  

A case of fungal keratitis caused by Petriella setifera infection

作　　者：齐洪梅 张莉 杜满 杨扬 郭晓婷 李鹏 石颖 鹿秀海 Qi Hongmei;Zhang Li;Du Man;Yang Yang;Guo Xiaoting;Li Peng;Shi Ying;Lu Xiuhai(Eye Institute of Shandong First Medical University,Eye Hospital of Shandong First Medical University(Shandong Eye Hospital),State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,School of Ophthalmology,Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属眼科研究所、山东第一医科大学附属眼科医院(山东省眼科医院)山东省眼科学重点实验室-省部共建国家重点实验室培育基地、山东第一医科大学眼科学院,济南250021

出　　处：《中华眼科杂志》2024年第2期176-179,共4页Chinese Journal of Ophthalmology

摘　　要：患者为66岁男性,右眼被木板崩伤后眼红伴视物不清、畏光、流泪,抗炎治疗效果不佳。右眼角膜中央可见4 mm×4 mm大小浸润灶伴表面白色苔被附着。角膜刮片显微镜检查、真菌培养及活体共聚焦显微镜检查均提示真菌感染。分离菌株经过镜下形态鉴定为尖端赛多孢霉,通过基因测序鉴定为刚毛黑孢壳菌。门诊给予角膜清创联合常规抗炎抗真菌治疗,随访期间病情持续好转,初诊40 d后复诊时裂隙灯显微镜检查发现角膜基质变薄,上皮基本愈合,裸眼视力由0.3提高到0.6。The patient,a 66-year-old male,suffered from redness,blurred vision,photophobia,and tearing in the right eye after being injured by a wooden board.Anti-inflammatory treatment showed poor effectiveness.A 4 mm×4 mm infiltrate with white deposits on the surface was observed in the central cornea of the right eye.Microscopic examination of corneal scrapings,fungal culture,and in vivo confocal microscopy all indicated fungal infection.The isolated strain was identified as Scedosporium apiospermum through microscopic morphology and confirmed as Petriella setifera by gene sequencing.The patient received corneal debridement combined with routine anti-inflammatory and antifungal treatment in the outpatient clinic.During the follow-up period,the condition continued to improve.Slit lamp examination at the revisit 40 days after the initial diagnosis revealed thinning of the corneal stroma,basic healing of the epithelium,and an increase in uncorrected visual acuity from 0.3 to 0.6.

关 键 词：子囊菌纲 角膜炎 眼感染 真菌性 刚毛黑孢壳菌 

分 类 号：R772.21[医药卫生—眼科]