胸腺上皮肿瘤微环境异常与自身免疫障碍发生的研究进展  

Progress on Abnormal Immune Microenvironment and Thymic Epithelial Tumors

作　　者：王佳惠 黄月雨 姚其峰 杨绪萍 应江华 高成根 周斌 余昶[2] 刘俊平[2] 叶雪梅[2] 王长春[2] 赵安[2,3,4] 毛伟敏 WANG Jiahui;HUANG Yueyu;YAO Qifeng;YANG Xuping;YING Jianghua;GAO Chenggen;ZHOU Bin;YU Chang;LIU Junping;YE Xuemei;WANG Changchun;ZHAO An;MAO Weimin(The Second School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310053,China;Zhejiang Cancer Hospital,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences,Hangshou 310022,China;Thoracic Tumor Laboratory,Jiangxi Provincial Cancer Hospital,Nanchang 330000,China;Zhejiang Provincial Key Laboratory of Thoracic Cancer Diagnosis and Treatment Technology Research,Hangzhou 310022,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江省肿瘤医院,中国科学院杭州医学研究所,浙江杭州310022 [3]江西省肿瘤医院胸部肿瘤实验室,江西南昌330000 [4]浙江省胸部肿瘤诊治技术研究重点实验室,浙江杭州310022

出　　处：《肿瘤学杂志》2024年第1期63-68,共6页Journal of Chinese Oncology

基　　金：国家自然科学基金面上项目资助(82172567);江西省重点研发项目(20212BBG71006)。

摘　　要：胸腺是T淋巴细胞发育及T细胞受体形成的重要器官,在适应性免疫和中枢耐受建立中发挥关键作用。祖T细胞在早期发育阶段由骨髓迁移至胸腺,经过与皮质及髓质区的胸腺上皮细胞相互作用,先凭借阳性选择再通过阴性选择分化为成熟T淋巴细胞,共同形成了胸腺独特的微环境。胸腺上皮肿瘤是前纵隔中常见的原发性肿瘤,异常增殖的上皮细胞常伴随大量的未成熟的淋巴细胞,造成自身免疫性临床症状,但其确切的分子调控机制与形成机制尚不清楚。全文综述胸腺上皮肿瘤微环境异常与自身免疫障碍发生的研究进展。The thymus is an important organ for T lymphocyte development and the formation of T-cell receptors,playing a critical role in adaptive immunity and central tolerance establishment.Progenitor T cells migrate from the bone marrow to the thymus during early developmental stages and interact with thymic epithelial cells in the cortical and medullary regions of thymus.Through positive and negative selection processes,these progenitor T cells differentiate into mature T lymphocytes,contributing to the unique microenvironment of the thymus.Thymic epithelial tumors are common primary tumors in the anterior mediastinum,characterized by the abnormal proliferation of epithelial cells often accompanied by a large number of immature lymphocytes,which can potentially lead to autoimmune clinical symptoms.However,the exact molecular regulatory mechanisms and the underlying pathogenesis of these tumors remain unclear.This paper reviews the research progress on the disruption of immune microenvironment in tymus during the occurrence and development of thymic epithelial tumors.

关 键 词：适应性免疫 前纵隔 异常增殖 原发性肿瘤 环境异常 T淋巴细胞 胸腺上皮细胞 阴性选择 

分 类 号：R736.3[医药卫生—肿瘤]