Efficacy of activating blood and resolving stasis therapy for IgA nephropathy:a systematic review and meta-analysis  

作　　者：Qiu-Mei Lan Jie Li Han-Qing Zang Zi-Jun Zhou Ya-Xuan Fang Yun-Ze Xing Bo Yang 

机构地区：[1]Department of Nephrology,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China [2]National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China

出　　处：《Medical Data Mining》2024年第2期9-16,共8页TMR医学数据挖掘

摘　　要：Background:To systematically evaluate the efficacy and safety of activating blood and resolving stasis in patients with IgA nephropathy.Methods:From inception to May 2022,databases including PubMed,Embase,the Cochrane Library,Web of Science,WanFang database,Chinese Biomedical Database,VIP,and China National Knowledge Infrastructure were searched for randomized controlled trials about enhancing blood circulation and removing stasis for IgA nephropathy.For the articles that satisfied the requirements,quality assessment and meta-analysis were done.Results:Seventeen randomized controlled trials with a total of 1653 patients were included.Meta-analysis showed that activating blood and resolving stasis could increase therapeutic effectiveness(risk ratio(RR)=-0.47,95%confidence interval(CI)(-0.37,-0.2),P=0.0006)and decrease levels of serum creatinine(RR=-0.47,95%CI(-0.37,-0.2),P=0.0006),urea nitrogen(RR=0.85,95%CI(1.44,0.26),P=0.005),24-hour urinary protein quantification(RR=1.6,95%CI(2.44,0.95).P=0.00001),and urine red blood cell count(RR=1.7,95%CI(2.57,0.82),P=0.0001).There was no significant difference between the two groups in terms of security(RR=0.6,95%CI(0.36,1.01),P=0.05).Conclusion:Western medicine combined activating blood and resolving stasis is more efficient than Western medicine therapy alone in treating IgA nephropathy,but it still needs to be supported by additional large-scale,multi-center randomized controlled clinical trials due to the poor quality of the included trials.

关 键 词：IgA nephropathy activating blood and resolving stasis META-ANALYSIS randomized controlled trial blood stasi 

分 类 号：R73[医药卫生—肿瘤]