乳腺癌患者放射治疗前后血清肝代谢酶CYP1A2水平和临床特征与放射性皮炎的相关性分析  

Correlation of the level of hepatic metabolic enzymes CYP1A2 in serum before and after radiotherapy and clinical characteristics with the radiation dermatitis in patients with breast cancer

作　　者：陈梓林 罗莲 周娜 颜磊 黄嘉琪 陈勇 CHEN Zilin;LUO Lian;ZHOU Na;YAN Lei;HUANG Jiaqi;CHEN Yong(Department of Hematology and Oncology Shaoyang Hospital Affiliated of University of South China,Shaoyang 422000,China)

机构地区：[1]南华大学附属邵阳医院血液肿瘤科,湖南邵阳422000

出　　处：《邵阳学院学报（自然科学版）》2024年第1期102-109,共8页Journal of Shaoyang University：Natural Science Edition

基　　金：邵阳市科学技术局重大专项和重点项目(2020NS36);邵阳市科学技术局一般项目(2021GZ037)。

摘　　要：目的探讨乳腺癌患者放射治疗前后血清中肝代谢酶CYP1A2水平和临床特征与放射性皮炎的相关性。方法选取本院2022年10月至2023年8月收治的IIA期乳腺癌放射治疗患者120例为研究对象。收集患者年龄、卡氏功能状态评分标准(kamofsky performance status,KPS)、体重指数(body mass index,BMI)资料。采用酶联免疫法检测患者放射治疗前后血清中CYP1A2的表达水平。根据放射性皮炎程度分为重度组(n=21)、轻度组(n=81)、正常组(n=18)。采用χ2检验分析放射治疗后放射性皮炎发生率与临床特性的相关性。采用Wilcoxon符号秩检验比较放射治疗前后血清CYP1A2水平的差异。采用Kruskal-Wallis H检验比较放射治疗后放射性皮炎程度不同组的血清CYP1A2水平的差异。结果放射治疗后放射性皮炎发生率为85%。放射治疗后重度组的血清CYP1A2水平为(5.43±0.99)ng/mL,轻度组为(3.67±1.08)ng/mL,正常组为(2.06±0.91)ng/mL。年龄、KPS、BMI与放射性皮炎发生率具有相关性,年龄≥60岁,KPS≤80分,BMI<18.5 kg/m^(2)的患者更容易发生放射性皮炎,差异有统计学意义(P<0.05)。放射治疗后血清CYP1A2水平较放射治疗前升高,差异具有统计学意义(P<0.05)。放射治疗后血清CYP1A2水平与放射治疗后放射性皮炎分级呈正相关(r=0.665,P<0.05)。结论乳腺癌患者年龄、KPS、BMI与放射治疗引起的放射性皮炎发生率有关,放射治疗后血清CYP1A2水平升高,且与放射性皮炎严重程度有关。Objective To explore the correlation of the level of hepatic metabolic enzymes CYP1A2 in serum before and after radiotherapy and clinical characteristics with the radiation dermatitis in patients with breast cancer.Methods A total of 120 patients with stage IIA breast cancer radiotherapy admitted to our hospital from October 2022 to August 2023 were selected as the study subjects.The patients’age,KPS and BMI information were collected.The expression level of CYP1A2 in serum before and after radiotherapy was detected by enzyme-linked immunoassay.According to the severity of radiation dermatitis,the patients were divided into severe group(n=21),mild group(n=81)and normal group(n=18).The correlation between the degree of radiation dermatitis and clinical characteristics after radiotherapy was analyzed by chi square test.The differences in serum CYP1A2 levels before and after radiotherapy were compared by Wilcoxon signed rank test.The differences in serum CYP1A2 levels among groups with different degrees of radiation dermatitis after radiotherapy by Kruskal Wallis H test were compared.Results The incidence of radiation dermatitis after radiotherapy was 85%.The serum CYP1A2 levels of radiation dermatitis after radiotherapy were(5.43±0.99)ng/mL in the severe group,(3.67±1.08)ng/mL in the mild group,and(2.06±0.91)ng/mL in the normal group.There was a correlation of age,KPS,BMI,with the incidence of radiation dermatitis.Patients aged≥60 years,KPS≤80 scores,and BMI<18.5 kg/m^(2) were more likely to develop radiation dermatitis,and the differences were statistically significant(P<0.05).The serum CYP1A2 level increased after radiotherapy compared to before radiotherapy,and the difference was statistically significant(P<0.05).The serum CYP1A2 level after radiotherapy was positively correlated with the severity of radiation dermatitis after radiotherapy(r=0.665,P<0.05).Conclusion Age,KPS and BMI of breast cancer patients are related to the incidence of radiation dermatitis caused by radiotherapy.The serum CYP1A2 leve

关 键 词：乳腺癌 肝代谢酶CYP1A2 放射治疗 放射性皮炎 

分 类 号：R737.9[医药卫生—肿瘤]