参梅养胃颗粒清膏粉的喷雾干燥工艺研究  

Study on Spray Drying Technology of Shenmei Yangwei Granules

作　　者：黄玉瑶 张洪坤 路丽 郝建新 仲勇成 王利胜[4] 董翼虎 高贯彪 Huang Yuyao;Zhang Hongkun;Lu Li;Hao Jianxin;Zhong Yongcheng;Wang Lisheng;Dong Yihu;Gao Guanbiao(Sichuan Haoyun Pharmaceutical Co.,Ltd.,Guangyuan 628017,China;Bozhou Huqiao Pharmaceutical Industry Limited Company,Bozhou 236800,China;Guangzhou Heyi Medical Technology Co.,Ltd.,Guangzhou 510970,China;Guangzhou University of Chinese Medicine,Guangzhou 510006,China;Guangyuan Drug Inspection and Testing Center,Guangyuan 628017,China)

机构地区：[1]四川豪运药业股份有限公司,四川广元628017 [2]亳州市沪谯药业有限公司,安徽亳州236800 [3]广州市和一医疗科技有限公司,广东广州510970 [4]广州中医药大学,广东广州510006 [5]广元市药品检验检测中心,四川广元628017

出　　处：《亚太传统医药》2024年第3期48-52,共5页Asia-Pacific Traditional Medicine

摘　　要：目的:优化参梅养胃颗粒清膏粉的喷雾干燥工艺。方法:采用Box-Behnken中心组合设计原理,设计进风温度、喷雾流量、浸膏密度3因素3水平响应面试验,建立模型并分析最优的工艺参数。结果:所得的回归模型拟合度高,优化后的工艺参数为进风温度195℃,喷雾流量4 Hz,浸膏密度1.09 g/mL。结论:所得参梅养胃颗粒清膏粉喷雾干燥工艺稳定可靠,为开发参梅养胃颗粒无糖制剂奠定了基础。Objective:To optimize the spray drying process of Shenmei Yangwei Granules.Methods:Based on the Box-Behnken center combination design principle,a three-factor three-level response surface test was designed for inlet air temperature,spray flow rate,and extract density.The model was established,and the optimal process parameters were analyzed.Results:The regression model fitted well.The optimized process parameters were air inlet temperature 195℃,spray flow rate 4Hz,and extract density 1.09 g/mL.Conclusion:The spray drying process of Shenmei Yangwei Granules was stable and reliable,which laid a foundation for the development of sugar-free preparations of Shenmei Yangwei Granules.

关 键 词：参梅养胃颗粒 清膏粉 喷雾干燥 响应面优化 

分 类 号：R283.6[医药卫生—中药学]