血清LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1水平与老年急性脑梗死的相关性研究  

Correlation between Serum LDL-C/HDL-C,Non-HDL-C,RLP-C and sLOX-1 Levels and Acute Cerebral Infarction in Elderly Patients

作　　者：张萌 刘海颖 齐畅 ZHANG Meng;LIU Haiying;QI Chang(Department of Neurology,the Fourth People's Hospital of Langfang City,Langfang,Hebei 065700,China;Department of Ultrasound,the Fourth People's Hospital of Langfang City,Langfang,Hebei 065700,China;Department of Clinical Laboratory,Beijing Ditan Hospital Affiliated to Capital Medical University,Beijing 100015,China)

机构地区：[1]廊坊市第四人民医院神经内科,河北廊坊065700 [2]廊坊市第四人民医院超声科,河北廊坊065700 [3]首都医科大学附属北京地坛医院检验科,北京100015

出　　处：《临床误诊误治》2024年第1期83-88,共6页Clinical Misdiagnosis & Mistherapy

基　　金：廊坊市科技支撑计划项目(2022013031)。

摘　　要：目的分析血清低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)、非高密度脂蛋白胆固醇(non-HDL-C)、残粒脂蛋白胆固醇(RLP-C)及可溶性凝集素样氧化型低密度脂蛋白受体-1(sLOX-1)水平与老年急性脑梗死(ACI)的相关性。方法选取2022年1月—2023年8月收治的230例老年ACI作为研究组,另选择同期、同年龄段115例健康体检者作为对照组。比较2组LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1水平,比较研究组不同斑块稳定性、神经功能缺损程度[采用美国国立卫生研究院卒中量表(NIHSS)评分评估]、颈动脉内中膜厚度(IMT)患者上述指标水平,偏回归分析上述指标与老年ACI的关系,并分析上述指标与斑块稳定性、IMT、NIHSS评分的相关性。结果研究组LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1水平高于对照组(P<0.01)。老年ACI患者LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1水平,无斑块患者<稳定斑块患者<不稳定斑块患者,轻度神经功能缺损患者<中度神经功能缺损患者<重度神经功能缺损患者,IMT正常患者<IMT增厚患者<斑块形成患者(P<0.05)。LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1水平与老年ACI密切相关(P<0.01)。研究组LDL-C/HDL-C、non-HDL-C、RLP-C及sLOX-1水平分别与斑块稳定性、IMT、NIHSS评分呈正相关(P<0.01)。结论老年ACI患者LDL-C/HDL-C、non-HDL-C、RLP-C、sLOX-1水平明显升高,且与神经功能缺损程度及颈动脉粥样硬化斑块密切相关。Objective To analyze the correlation of the levels of serum low-density lipoprotein cholesterol(LDL-C)/high-density lipoprotein cholesterol(HDL-C),non-high-density lipoprotein cholesterol(non-HDL-C),residual lipoprotein cholesterol(RLP-C)and soluble Lectin-like oxidized low density lipoprotein receptor-1(sLOX-1)with acute cerebral infarction(ACI).Methods A total of 230 elderly ACI patients admitted from January 2022 to August 2023 were selected as the research group,and 115 healthy physical examinees of the same age group during the same period were selected as the control group.The levels of LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 were compared between the two groups,and the above levels of patients with different plaque stability,neurological deficit[assessed by the National Institutes of Health Stroke Scale(NIHSS)score]and carotid intimedia thickness(IMT)in the research group were compared.Partial regression analysis was performed to analyze the relationship between the above indexes and ACI,and the correlation between the above indexes and plaque stability,IMT and NIHSS score.Results LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in the research group were higher than those in the control group(P<0.01).For elderly ACI patients,LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were lower in non-plaque patients,followed by stable plaque patients and unstable plaque patients,lower in mild neurological deficit patients,followed by moderate neurological deficit patients and severe neurological deficit patients,and lower in normal IMT patients,followed by IMT thickening patients and plaque formation patients(P<0.05).LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels were closely correlated with ACI in the elderly(P<0.01).LDL-C/HDL-C,non-HDL-C,LDL-C and sLOX-1 levels in the research group were positively correlated with plaque stability,IMT and NIHSS score,respectively(P<0.01).Conclusion LDL-C/HDL-C,non-HDL-C,RLP-C and sLOX-1 levels in elderly ACI patients are significantly increased,which is closely related to the degree of n

关 键 词：急性脑梗死 低密度脂蛋白胆固醇 高密度脂蛋白胆固醇 非高密度脂蛋白胆固醇 残粒脂蛋白胆固醇 可溶性凝集素样氧化低密度脂蛋白受体-1 老年人 相关性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]