急性白血病治疗与儿童及青少年患者远期卵巢功能的研究进展  

Advances in treatment of acute leukemia and long-term ovarian function in children and adolescents

作　　者：吴树青 何红波 李文京[3] 张瑞东[2] 于皎乐 Wu Shuqing;He Hongbo;Li Wenjing;Zhang Ruidong;Yu Jiaole(The Second Clinical Medical College,Capital Medical University,Beijing 100050,China;Hematology Center,Beijing Children′s Hospital,School of Pediatric Medicine,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Endocrinology,Genetics and Metabolism,Beijing Children′s Hospital,School of Pediatric Medicine,Capital Medical University,National Center for Children′s Health,Beijing 100045,China;Department of Hematology&Oncology,Baoding Hospital,Beijing Children′s Hospital,Capital Medical University,Baoding 071030,China)

机构地区：[1]首都医科大学第二临床医学院,北京100050 [2]首都医科大学儿科医学院、首都医科大学附属北京儿童医院血液病中心、国家儿童医学中心,100045 [3]首都医科大学儿科医学院、首都医科大学附属北京儿童医院内分泌遗传代谢科、国家儿童医学中心,100045 [4]首都医科大学附属北京儿童医院保定医院血液肿瘤病区,071030

出　　处：《国际儿科学杂志》2024年第1期6-11,共6页International Journal of Pediatrics

基　　金：北京市医院管理局青苗人才计划(QML20161202);首都医科大学本科生科研创新项目(XSKY2023331);河北省重点研发计划卫生健康创新专项(22377737D)。

摘　　要：急性白血病(acute leukemia,AL)是儿童及青少年时期常见的血液系统恶性肿瘤。化疗是目前临床上AL主要的治疗方式。造血干细胞移植、靶向治疗、免疫治疗等疗法也为难治/复发患者的生存带来更大的希望。化疗药物、放疗、靶向和免疫药物在进行临床应用的同时,会在其他非靶系统产生不良反应,其中对生殖系统的不良作用可能导致患者面临无法生育的困境,降低长期生存质量。随着AL患者生存率不断地提升,需明确不同治疗方案对性腺功能的影响,针对性进行改进与预防,促使患者生存质量随着生命长度的延长而同步提高。该文旨在综述AL治疗对女性儿童及青少年患者卵巢功能的影响,为临床白血病患者远期生殖保护提供思路。Acute leukemia(AL)is a common hematological malignancy in children and adolescents.Chemotherapy is currently the primary treatment for AL.Alternative therapies,such as hematopoietic stem cell transplantation(HSCT),targeted therapy,and immunotherapy also offer greater hope for the survival of refractory/relapsed patients.Chemotherapeutic drugs,radiotherapy,targeted drugs and immunotherapeutic drugs are well-applied clinically,meanwhile posing threats to non-target systems.The adverse effects on the reproductive system may lead to the dilemma of infertility,thus reducing the long-term quality of life.As the survival rate of AL patients keeps increasing continuously,the influence of different treatments on the gonad function needs to be clarified.With the help of targeted fertility prevention,the patient′s quality of life can be enhanced in parallel with life span.This article aims to review the impact of AL treatment on ovarian function in female children and adolescents and provide ideas for the long-term fertility protection of leukemia patients.

关 键 词：急性白血病 儿童及青少年 化疗 造血干细胞移植 卵巢功能 

分 类 号：R733.71[医药卫生—肿瘤]