分析艾司西酞普兰联合米安色林对抑郁患者睡眠质量及认知功能的影响  

Analysis of the Effects of Escitalopram Combined with Mianserin on Sleep Quality and Cognitive Function in Patients with Depression

作　　者：姜德利 JIANG Deli(Yantai Psychological Rehabilitation Hospital,Shandong Province,Yantai 265200,China)

机构地区：[1]山东省烟台市心理康复医院,烟台265200

出　　处：《世界睡眠医学杂志》2023年第11期2563-2565,共3页World Journal of Sleep Medicine

摘　　要：目的:分析艾司西酞普兰联合米安色林对抑郁患者睡眠质量及认知功能的影响。方法:选取2020年2月至2023年2月山东省烟台市心理康复医院精神科收治的抑郁障碍患者86例作为研究对象,按照随机抽样法分为对照组和观察组,每组43例,对照组患者给予艾司西肽普兰治疗,观察组在对照组基础上联合给予米安色林治疗。采用汉密尔顿抑郁量表(HAMD)比较2组患者干预前后抑郁状态的改善效果,采用匹兹堡睡眠质量指数(PSQI)比较2组患者睡眠质量的差异,采用蒙特利尔认知评估表(MoCA)比较2组患者干预前后的认知功能,并比较2组患者干预前后治疗的有效率。结果:治疗后,观察组治疗的总有效率显著高于对照组,观察组PSQI评分、HAMD评分显著低于对照组,观察组MoCA评分显著高于对照组,差异均有统计学意义(均P<0.05)。结论:抑郁障碍患者通过艾司西肽普兰、米安色林联合治疗后,能够取得满意疗效,使患者的睡眠质量和认知功能情况得到改善,值得临床推广使用。Objective:To analyze the effects of escitalopram combined with mianserin on sleep quality and cognitive function in patients with depression.Methods:A total of 86 patients with depression admitted to the Department of Psychiatry at Yantai Psychological Rehabilitation Hospital in Shandong Province from February 2020 to February 2023 were selected as the study subjects.They were randomly divided into an observation group(n=43) and a control group(n=43).The control group received treatment with escitalopram,while the observation group received combined treatment with mianserin on the basis of the control group.The Hamilton Depression Rating Scale(HAMD) was used to compare the improvement effect of depression status between two groups of patients before and after intervention.The Pittsburgh Sleep Quality Index(PSQI) was used to compare the differences in sleep quality between the two groups of patients.The Montreal Cognitive Assessment Scale(MoCA) was used to compare the cognitive function of the two groups of patients before and after intervention,And compare the effectiveness of treatment between the two groups of patients before and after intervention.Results:After treatment,the total effective rate of the observation group was significantly higher than that of the control group.The PSQI score and HAMD score of the observation group were significantly lower than those of the control group,and the MoCA score of the observation group was significantly higher than that of the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion:After the combination treatment of escitalopram and mianserin,patients with depression can achieve satisfactory therapeutic effects,improve their sleep quality and cognitive function,and are worthy of clinical promotion and use.

关 键 词：抑郁症 艾司西肽普兰 米安色林 睡眠质量 认知功能 

分 类 号：R749.41[医药卫生—神经病学与精神病学] R338.63[医药卫生—临床医学]