黄连温胆汤加味和右佐匹克隆联合治疗卒中后睡眠障碍痰热内扰证的临床分析  

Clinical Analysis of Modified Huanglian Wendan Decoction and Right Zopiclone Combined Treatmentfor Poststroke Sleep Disorder with Phlegm Heat Internal Disturbance Syndrome

作　　者：吴仕福 刘小团 WU Shifu;LIU Xiaotuan(Xiamen Hospital of Beijing University of Traditional Chinese Medicine,Xiamen 361012,China)

机构地区：[1]北京中医药大学厦门医院,厦门361012

出　　处：《世界睡眠医学杂志》2023年第12期2800-2803,共4页World Journal of Sleep Medicine

摘　　要：目的:分析黄连温胆汤加味和右佐匹克隆联合治疗卒中后睡眠障碍痰热内扰证的临床效果。方法:选取2021年4月至2022年10月北京中医药大学厦门医院收治的卒中后睡眠障碍痰热内扰症患者86例作为研究对象分为对照组和观察组,每组43例,对照组给予右佐匹克隆干预治疗,观察组给予黄连温胆汤加味联合右佐匹克隆治疗。采用匹兹堡睡眠质量指数(PSQI)比较2组患者干预前后睡眠质量的变化,采用汉密尔顿抑郁量表(HAMD)比较2组患者干预前后抑郁状态的改善效果,采用中医证候积分对患者的不寐、心烦、胸闷脘痞等中医证候积分进行评价,采用Barthel指数比较2组患者干预前后的日常生活活动能力,并比较2组患者干预前后的治疗效果。结果:干预后,观察组的治疗有效率显著高于对照组,观察组PSQI评分、HAMD评分显著低于对照组,观察组Barthel指数评分高于对照组,观察组患者在治疗后的不寐积分、心烦积分、胸闷脘痞积分低于对照组,差异均有统计学意义(均P<0.05)。结论:在卒中后睡眠障碍痰热内扰证的临床治疗中,黄连温胆汤加味联合应用右佐匹克隆具有良好的应用疗效,能够有效改善患者的睡眠质量,缓解患者的抑郁状态,缓解患者的不寐、心烦、胸闷脘痞等中医证候症状,提高患者的日常生活能力,值得临床推广应用。Objective:To analyze the clinical efficacy of modified Huanglian Wendan Decoction and the combination of right zopiclone in the treatment of post-stroke sleep disorders with phlegm heat disturbance syndrome.Methods:A total of 86 patients with post-stroke sleep disorders with phlegm heat disturbance syndrome admitted to Xiamen Hospital of Beijing University of Traditional Chinese Medicine from April 2021 to October 2022 were selected as the study subjects.They were divided into an observation group(n=43)and a control group(n=43).The control group received intervention treatment with right zopiclone,while the observation group received treatment with modified Huanglian Wendan Decoction combined with right zopiclone.The Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes in sleep quality between two groups of patients before and after intervention.The Hamilton Depression Scale(HAMD)was used to compare the improvement effect of depression status between the two groups of patients before and after intervention.Traditional Chinese Medicine syndrome scores were used to evaluate the scores of traditional Chinese medicine syndromes such as insomnia,restlessness,chest tightness,and abdominal distension.The Barthel index was used to compare the daily living activities of the two groups of patients before and after intervention,and the treatment effects of the two groups of patients before and after intervention were compared.Results:After intervention,the effective rate of treatment in the observation group was significantly higher than that in the control group.The PSQI score and HAMD score in the observation group were significantly lower than those in the control group.The Barthel index score in the observation group was higher than that in the control group.Patients in the observation group had lower scores for insomnia,restlessness,and chest tightness and abdominal distension after treatment compared to the control group.The differences between the two groups were statistically significant(P s<0.05).Con

关 键 词：黄连温胆汤 右佐匹克隆 卒中后睡眠障碍 痰热内扰证 抑郁 生活能力 

分 类 号：R364.13[医药卫生—病理学] R338.63[医药卫生—基础医学]