内分泌疾病与非酒精性脂肪性肝病  

Endocrine disease and nonalcoholic fatty liver disease

作　　者：曹欢易 关海霞 傅晓莹 CAO Huan-yi;GUAN Hai-xia;FU Xiao-ying(Department of Endocrinology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China)

机构地区：[1]南方医科大学附属广东省人民医院,广东省医学科学院内分泌科,广东广州510080

出　　处：《中国实用内科杂志》2024年第1期11-16,共6页Chinese Journal of Practical Internal Medicine

基　　金：国家自然科学基金青年科学基金(82300956)。

摘　　要：非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是常见的慢性肝脏疾病之一,既往报道其主要与代谢综合征组分(如血脂异常、肥胖及2型糖尿病)导致的胰岛素抵抗有关。近年来,越来越多的研究发现多种内分泌疾病可能也与NAFLD相关,包括甲状腺功能减退症、多囊卵巢综合征(polycystic ovarian syndrome,PCOS)、生长激素缺乏症(growth hormone deficiency,GHD)以及性腺功能减退症等。这些引起内分泌功能障碍的疾病不仅能够导致NAFLD疾病的发生发展,也与NAFLD疾病的严重程度密切相关。文章通过概述不同内分泌疾病中NAFLD的流行病学及病理生理学的相关证据,提醒读者进一步认识和关注临床实践中可能遇到的内分泌疾病相关NAFLD。Nonalcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver diseases,mainly related to insulin resistance caused by metabolic syndrome(such as dyslipidemia,obesity,and type 2 diabetes mellitus).In recent years,increasing evidence has suggested that many endocrine diseases may also be associated with NAFLD,including hypothyroidism,polycystic ovary syndrome(PCOS),growth hormone deficiency(GDH),and hypogonadism.These endocrine diseases could not only promote the development and progression of NAFLD but also aggravate the clinical characteristics of NAFLD.Here,we summarized the updated evidence on the epidemiology and pathophysiology of NAFLD in different endocrine diseases.Further,we aim to remind readers to understand and pay attention to endocrine diseaserelated NAFLD that may be encountered in clinical practice.

关 键 词：内分泌疾病 非酒精性脂肪肝病 甲状腺功能减退症 多囊卵巢综合征 性腺功能减退症 生长激素缺乏症 

分 类 号：R575[医药卫生—消化系统]