针刺组穴调节无先兆偏头痛患者即刻效应的静息态功能MRI探讨  

Study of resting-state functional MRI on immediate effect regulated by acupuncture on acupoints in patients with migraine without aura

作　　者：张亚男[1] 刘妮 任蒙蒙 洪月颖 张健睿 张磊[1] 罗煊之 刘慧林[2] 霍健伟 韩芳 ZHANG Ya'nan;LIU Ni;REN Mengmeng;HONG Yueying;ZHANG Jianrui;ZHANG Lei;LUO Xuanzhi;LIU Huilin;HUO Jianwei;HAN Fang(Department of Radiology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Department of Acupuncture and Moribustion,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Office of Academic Research,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]首都医科大学附属北京中医医院放射科,北京100010 [2]首都医科大学附属北京中医医院针灸科,北京100010 [3]首都医科大学附属北京中医医院科研处,北京100010

出　　处：《实用放射学杂志》2024年第1期11-14,共4页Journal of Practical Radiology

基　　金：北京市属医院科研培育项目(PZ2021016);北京市医院管理中心培育计划项目(PZ2020013)。

摘　　要：目的探讨针刺调节无先兆偏头痛(MwoA)患者发作间期的即刻效应机制。方法纳入28例MwoA患者,并于基线及针刺30min后行静息态功能磁共振成像(rs-fMRI)检查。应用配对t检验比较2组局部一致性(ReHo)和体素镜像同伦功能连接(VMHC)差异。分析rs-fMRI各指标变化与临床评分的相关性。结果与基线相比,针刺30min后MwoA患者右侧舌回、右侧小脑的均值局部一致性(mReHo)减低,右侧额中回mReHo升高,而患者双侧楔叶z变换体素镜像同伦功能连接(zVMHC)明显降低。影像学数据与临床量表无明显相关性。结论针刺MwoA患者出现多个脑区ReHo和VMHC的异常,其即刻效应机制可能是通过调节疼痛相关脑区发挥作用。Objective To explore the mechanism of immediate effect regulated by acupuncture on acupoints in patients with migraine without aura(MwoA)during the interictal period.Methods sA total of 28 MwoA patients were enrolled and resting-state functional magnetic resonance imaging(rs-fMRI)were performed at baseline and after acupuncture for 30 minutes.Paired t test was used to compare the differences of regional homogeneity(ReHo)and voxel-mirrored homotopic connectivity(VMHC)between two groups.Additionally,the correlation between the changes of rs-fMRI indexes and clinical scores was analyzed.Results In MwoA patients after acupuncture for 30 minutes,the mean regional homogeneity(mReHo)was decreased in the right lingual gyrus and right cerebellum and was increased in the right middle frontal gyrus,while the z transformation voxel-mirrored homotopic connectivity(zVMHC)was significantly decreased in the bilateral cuneus compared with baseline.There was no significant correlation between imaging data and clinical scales.Conclusion Patients with MwoA after acupuncture for 30 minutes show abnormal ReHo and VMHC in multiple brain regions,which suggest that the mechanism of immediate effect may act through regulating pain-related brain regions.

关 键 词：偏头痛 发作间期 针刺 即刻效应 局部一致性 体素镜像同伦功能连接 

分 类 号：R747.2[医药卫生—神经病学与精神病学] R245.31[医药卫生—临床医学] R445.2