扩散加权成像和T_(2)^(*)mapping评估头颈部肿瘤患者不同放疗时间段腮腺功能  

Application value of diffusion weighted imaging and T_(2)^(*)mapping of parotid gland function in patients with head and neck tumors at different radiotherapy periods

作　　者：蒲晓琦 甘继瑞 袁泉 PU Xiaoqi;GAN Jirui;YUAN Quan(Department of Diagnostic Radiology,China-Japan Friendship Hospital,Beijing 100029,China;Department of Education,China-Japan Friendship Hospital,Beijing 100029,China;Department of Traditional Chinese Medicine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院放射诊断科,北京100029 [2]中日友好医院教育处,北京100029 [3]中日友好医院中医外科,北京100029

出　　处：《实用放射学杂志》2024年第1期22-26,共5页Journal of Practical Radiology

摘　　要：目的探讨MR扩散加权成像(DWI)和T_(2)^(*)mapping在头颈部肿瘤患者不同放疗时间段腮腺功能的应用价值。方法选取82例头颈部肿瘤患者,收集患者腮腺体积、唾液量和腮腺功能参数,采用MRDWI和T_(2)^(*)mapping测定腮腺组织表观扩散系数(ADC)值和T_(2)^(*)值,分析腮腺功能与影像学数值的相关性。结果不同放疗时间段腮腺体积、唾液量和分泌指数差异有统计学意义,且放疗中和放疗后腮腺体积、唾液量和分泌指数明显低于放疗前。不同放疗时间段T_(2)^(*)值差异有统计学意义,且放疗中和放疗后T_(2)^(*)值明显低于放疗前。不同放疗时间段ADC值差异有统计学意义,且放疗中和放疗后ADC值明显高于放疗前。ADC值分别与腮腺体积、唾液量和分泌指数呈负相关(r=-0.436,-0.730,-0.718,P<0.001);T_(2)^(*)值分别与腮腺体积、唾液量和分泌指数呈正相关(r=0.430,0.720,0.707,P<0.001)。结论不同放疗时间段腮腺体积、分泌指数和唾液量等腮腺功能指标呈现异常表达状态,而MRDWI与腮腺功能呈负相关,T_(2)^(*)mapping与腮腺功能呈正相关。Objective To explore the application value of MR diffusion weighted imaging(DWI)and T_(2)^(*)mapping of parotid gland function in patients with head and neck tumors at different radiotherapy periods.Methods A total of 82 patients with head and neck tumors treated were selected.The data of parotid gland volume,salivary volume and parotid gland function were collected.MR DWI and T_(2)^(*)mapping were used to measure the apparent diffusion coefficient(ADC)value and T_(2)^(*)value of parotid gland tissue,and the correlation between parotid gland function and imaging values were analyzed.Results There were all significant differences in parotid gland volume,salivary volume and secretion index among different radiotherapy periods,and parotid gland volume,salivary volume and secretion index during and after radiotherapy were significantly lower than those before radiotherapy.There were significant differences in T_(2)^(*)values among different radiotherapy periods,and T_(2)^(*)value during and after radiotherapy was significantly lower than that before radiotherapy.There were significant differences in ADC values among different radiotherapy periods,and the ADC value during and after radiotherapy was significantly higher than that before radiotherapy.ADC value was negatively correlated with parotid gland volume,salivary volume and secretion index(r=-0.436,0.730,-0.718,respectively,P<0.001),while the T_(2)^(*)value was positively correlated with parotid gland volume,salivary volume and secretion index(r=0.430,0.720,0.707,respectively,P<0.001).Conclusion Parotid gland volume,secretion index and salivary volume show abnormal levels at different radiotherapy periods.MR DWIis negatively correlated with parotid gland function,while T_(2)^(*)mapping is positively correlated with parotid gland function.

关 键 词：头颈部肿瘤 腮腺功能 扩散加权成像 T_(2)^(*)mapping 

分 类 号：R739.91[医药卫生—肿瘤] R445.2[医药卫生—临床医学]