肥胖在胃食管反流病发生发展中的作用机制  

Mechanism of obesity in the occurrence and development of gastroesophageal reflux disease

作　　者：玉素江·图荪托合提 麦麦提艾力·麦麦提明 艾克拜尔·艾力[2] Tusuntuoheti Yusujiang;Maimaitiming Maimaitiaili;Aili Aikebaier(Graduate School of Medicine,Xinjiang Medical University,Urumqi 830054,China;Department of Minimally Invasive Surgery,Hernia and Abdominal Wall Surgery,Research Institute of General and Minimally Invasive Surgery,Xinjiang Clinical Research Center for Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830054 [2]新疆维吾尔自治区人民医院微创、疝和腹壁外科、普外微创研究所、新疆胃食管反流病与减重代谢外科临床医学研究中心,乌鲁木齐830001

出　　处：《中华消化外科杂志》2024年第1期147-152,共6页Chinese Journal of Digestive Surgery

基　　金：自治区重点研发任务专项(2022395588);国家自然科学基金(82060166)。

摘　　要：肥胖是胃食管反流病(GERD)的主要危险因素之一。随着社会经济发展,全世界肥胖人群呈持续增长趋势,导致GERD发病率升高。肥胖(尤其是中心型肥胖)与GERD密切相关。肥胖引起的腹腔内压力升高通过多种机械机制破坏胃食管"抗反流屏障",而肥胖人群内脏脂肪组织产生的多种细胞因子可能通过多种生物效应有利于GERD的发生发展。笔者从机械效应和生物效应探讨肥胖在GERD发生、发展中的作用机制,旨在帮助临床医师提高对GERD的认识。Obesity is one of the main risk factors for gastroesophageal reflux disease(GERD).With the development of social economy,the global obesity population shows a continuous growth trend,leading to an increase in the incidence rate of GERD.Obesity,especially the central obesity,is closely related to GERD.The increase of intra-abdominal pressure caused by obesity may lead to the destruction of"anti-reflux barrier"through a variety of mechanical mechanisms,and the various cytokines produced by visceral adipose tissue in obesity population may contribute to the occurr-ence and development of GERD through various biological effects.The authors explore the mechanism of obesity in the occurrence and development of GERD from both mechanical and biological effects,aiming to help clinical physicians improve their understanding of GERD.

关 键 词：胃食管反流 肥胖症 机械效应 生物效应 腰围 细胞因子 

分 类 号：R571[医药卫生—消化系统] R589.2[医药卫生—内科学]