百色市及周边地区胰腺癌发病相关危险因素分析  

A case-control study on risk factors for pancreatic cancer in Baise city and its surrounding areas

作　　者：黄秀权 岑兰英 王语阳 苏拾香 甘慧芳 徐键 黄桂香[1,2] 覃忠帅 覃月秋 Huang Xiuquan;Cen Lanying;Wang Yuyang;Su Shixiang;Gan Huifang;Xu Jian;Huang Guixiang;Qin Zhongshuai;Qin Yueqiu(Department of Gastroenterology,The Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)

机构地区：[1]右江民族医学院附属医院消化内科,广西百色533000 [2]右江民族医学院研究生学院,广西百色533000

出　　处：《右江民族医学院学报》2024年第1期18-23,共6页Journal of Youjiang Medical University for Nationalities

基　　金：国家自然科学基金项目(82260134);右江民族医学院附属医院高层次人才科研项目(R202011702)。

摘　　要：目的探讨百色市及周边地区胰腺癌发病可能相关的危险因素。方法回顾性分析2015年1月至2023年6月期间在右江民族医学院附属医院确诊为胰腺癌且病历资料完整的269例患者和同期因腹部不适住院并排除为患有肿瘤疾病的332例患者的临床资料,采用单因素及多因素二元Logistic回归分析性别、年龄、体重指数、吸烟史、饮酒史、高血压病史、糖尿病史、乙型肝炎病毒感染史、幽门螺杆菌感染史、血脂情况、胆系疾病史、慢性胰腺炎病史、家族史及遗传病史等资料,寻找胰腺癌发病的独立危险因素。结果单因素分析显示:吸烟史、饮酒史、高血压病史、糖尿病史、乙型肝炎病毒感染史、幽门螺杆菌感染史、高脂血症、慢性胰腺炎病史及胆系疾病史是胰腺癌发病的危险因素;多因素分析表明:吸烟史(OR=2.972)、高血压病史(OR=5.279)、糖尿病史(OR=35.819)、幽门螺杆菌感染史(OR=24.999)、高脂血症(OR=12.665)、胆系疾病史(OR=16.611)是胰腺癌发病的危险因素。结论本地区胰腺癌发病可能的危险因素有吸烟史、高血压病史、糖尿病史、幽门螺杆菌感染史、高脂血症、胆系疾病史,通过引导有以上疾病的人群积极进行胰腺癌筛查,对本地区胰腺癌的防治工作可以起到积极作用。Objective To investigate the risk factors for pancreatic cancer in Baise city and its surrounding areas.Methods This study retrospectively analyzed the clinical data of 269 patients diagnosed with pancreatic cancer with complete medical records in the Affiliated Hospital of Youjiang Medical University for Nationalities from January 2015 to June 2023 and the data of 332 patients who were hospitalized with abdominal discomfort and excluded as having tumor disease during the same period.Univariate and multivariate Logistic regression were adopted to analyze the data on their gender,age,body mass index,smoking history,drinking history,hypertension history,diabetes history,hepatitis B virus infection history,Helicobacter pylori infection history,blood lipid status,biliary disease history,chronic pancreatitis history,family history and genetic history,so as to find independent risk factors for pancreatic cancer.Results Univariate analysis showed that smoking history,drinking history,hypertension history,diabetes history,hepatitis B virus infection history,Helicobacter pylori infection history,hyperlipidemia,chronic pancreatitis history and biliary disease history were risk factors for pancreatic cancer.Multivariate analysis showed that smoking history(OR=2.972),hypertension history(OR=5.279),diabetes history(OR=35.819),Helicobacter pylori infection history(OR=24.999),hyperlipidemia(OR=12.665),biliary disease history(OR=16.611)were independent risk factors for pancreatic cancer.Conclusion The possible risk factors of pancreatic cancer in this area are smoking history,hypertension history,diabetes history,Helicobacter pylori infection history,hyperlipidemia and biliary disease history.By guiding people with these diseases to actively screen for pancreatic cancer,it can play a positive role in the prevention and treatment of pancreatic cancer in this area.

关 键 词：胰腺肿瘤 高血压 糖尿病 危险因素 

分 类 号：R735.9[医药卫生—肿瘤]