非小细胞肺癌患者的^(18)F-FDG PET/CT代谢参数与临床病理特征的关系研究  

A study on the relationship between^(18)F-FDG PET/CT metabolic parameters and clinicopathological characteristics in patients with non-small cell lung cancer

作　　者：郏振功 李辉 郑家雷 胡永全 Jia Zhengong;Li Hui;Zheng Jialei;Hu YongQuan(Department of Nuclear Medicine,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233004,Anhui,China;Department of Oncology,The First Affiliated Hospital of Bengbu Medical University,Bengbu 233004,Anhui,China)

机构地区：[1]蚌埠医科大学第一附属医院核医学科,安徽蚌埠233004 [2]蚌埠医科大学第一附属医院肿瘤内科,安徽蚌埠233004

出　　处：《右江民族医学院学报》2024年第1期78-84,共7页Journal of Youjiang Medical University for Nationalities

基　　金：蚌埠医学院自然科学重点项目(2021byzd126);安徽省高校自然科学研究重点项目(2023AH052016)。

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者的^(18)F-FDG PET/CT代谢参数与其临床病理特征之间的关系,并评估这些代谢参数在NSCLC诊断和分期中的潜在价值。方法进行回顾性研究,收集了85例2022年1月至2023年7月期间在本院PET/CT中心接受^(18)F-FDG PET/CT检查的NSCLC患者的临床资料。收集包括体质量指数(BMI)、吸烟史、病理类型、肿瘤位置、TNM分期、肿瘤直径、淋巴结转移、CYFRA 21-1表达、EGFR突变和PD-L1表达在内的临床病理特征。通过医学影像处理软件分析^(18)F-FDG PET/CT代谢参数,包括SUV_(max)、MTV和TLG。比较不同临床病理特征患者的代谢参数,并评估这些参数对疾病特征的诊断效能。结果在一般特征方面,如BMI和吸烟史,两组患者的代谢参数差异无统计学意义(P>0.05)。在病理类型、肿瘤位置、TNM分期、肿瘤直径、淋巴结转移、CYFRA 21-1表达、EGFR突变和PD-L1表达方面,代谢参数差异有统计学意义(P<0.05)。SUV_(max)、MTV和TLG在识别病理类型、TNM分期、肿瘤直径、淋巴结转移、EGFR突变和PD-L1表达方面具有较好的诊断效能(AUC=0.7~0.9,P<0.05)。在识别肿瘤位置和CYFRA 21-1表达方面,这些参数的诊断效能尚可(AUC=0.6~0.7,P<0.05)。结论^(18)F-FDG PET/CT代谢参数(SUV_(max)、MTV和TLG)对NSCLC患者的病理类型、分期、肿瘤直径、淋巴结转移、EGFR突变和PD-L1表达具有潜在的诊断价值。这些参数可以为NSCLC的个性化治疗和预后评估提供有力支持。Objective To investigate the relationship between^(18)F-FDG PET/CT metabolic parameters and clinicopathological characteristics in patients with non-small cell lung cancer(NSCLC)and evaluate the potential value of these metabolic parameters in the diagnosis and staging of NSCLC.Methods As a retrospective study,this study collected the clinical data of 85 NSCLC patients who underwent^(18)F-FDG PET/CT examinations at our PET/CT center from January 2022 to July 2023.Clinicopathological characteristics including body mass index(BMI),smoking history,pathological type,tumor location,TNM staging,tumor diameter,lymph node metastasis,CYFRA 21-1 expressions,EGFR mutations,and PD-L1 expressions were collected.Medical imaging software was used to analyze^(18)F-FDG PET/CT metabolic parameters,including SUV_(max),MTV,and TLG.The metabolic parameters of patients with different clinicopathological characteristics were compared,and the diagnostic performance of these parameters for disease characteristics was assessed.Results In general characteristics such as BMI and smoking history,there was no statistically significant difference in metabolic parameters between two groups(P>0.05).The metabolic parameters were significantly different in pathological type,tumor location,TNM stage,tumor diameter,lymph node metastasis,CYFRA 21-1 expressions,EGFR mutation and PD-L1 expression(P<0.05).SUV_(max),MTV,and TLG showed good diagnostic performance in identifying pathological type,TNM staging,tumor diameter,lymph node metastasis,EGFR mutations,and PD-L1 expression(AUC=0.7~0.9,P<0.05).These parameters also showed good diagnostic performance in identifying tumor location and CYFRA 21-1 expressions(AUC=0.6~0.7,P<0.05).Conclusion^(18)F-FDG PET/CT metabolic parameters(SUV_(max),MTV,and TLG)have potential diagnostic value for pathological type,staging,tumor diameter,lymph node metastasis,EGFR mutations,and PD-L1 expressions in NSCLC patients.These parameters can provide strong support for personalized treatment and prognostic evaluation of NSCLC.

关 键 词：癌 非小细胞肺 18 F-FDG PET/CT 代谢参数 病理类型 

分 类 号：R730.26[医药卫生—肿瘤]