Titanium particles in peri-implantitis:distribution,pathogenesis and prospects  

作　　者：Long Chen Zian Tong Hongke Luo Yuan Qu Xinhua Gu Misi Si 

机构地区：[1]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou,China [2]Department of Stomatology,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China [3]Zhejiang University-University of Edinburgh Institute,International Campus,Zhejiang University,Haining,China

出　　处：《International Journal of Oral Science》2023年第4期588-600,共13页国际口腔科学杂志（英文版）

基　　金：the National Natural Science Foundation of China(No.82170992,No.82201051 and No.82370990);Medical Health Science and Technology Project of Zhejiang Provincial Health Commission(WKJ-ZJ-2335);Innovative Talent of Zhejiang Provincial Health Commission,China Postdoctoral Science Foundation(2022M722742);2022 General Scientific Research Project of Zhejiang Education Department(Natural Science)(Y202249943).

摘　　要：Peri-implantitis is one of the most important biological complications in the field of oral implantology.Identifying the causative factors of peri-implant inflammation and osteolysis is crucial for the disease’s prevention and treatment.The underlying risk factors and detailed pathogenesis of peri-implantitis remain to be elucidated.Titanium-based implants as the most widely used implant inevitably release titanium particles into the surrounding tissue.Notably,the concentration of titanium particles increases significantly at peri-implantitis sites,suggesting titanium particles as a potential risk factor for the condition.Previous studies have indicated that titanium particles can induce peripheral osteolysis and foster the development of aseptic osteoarthritis in orthopedic joint replacement.However,it remains unconfirmed whether this phenomenon also triggers inflammation and bone resorption in peri-implant tissues.This review summarizes the distribution of titanium particles around the implant,the potential roles in peri-implantitis and the prevalent prevention strategies,which expects to provide new directions for the study of the pathogenesis and treatment of peri-implantitis.

关 键 词：TITANIUM TITANIUM DISTRIBUTION 

分 类 号：R783.5[医药卫生—口腔医学]