充气式保温毯联合多模式体温干预在非小细胞肺癌手术中的应用  

Application of an inflatable thermal blanket combined with multimodal body temperature intervention in non-small cell lung cancer surgery

作　　者：杨瑶 何文文 臧敏 YANG Yao;HE Wenwen;ZANG Min(Department of Anesthesia and Perioperative Medicine,Suqian First Hospital(Suqian Branch,Jiangsu Province Hospital),Jiangsu,Jiangsu 223800,China)

机构地区：[1]江苏省宿迁市第一人民医院(江苏省人民医院宿迁分院)麻醉与围术期医学科,223800

出　　处：《河北医药》2024年第3期340-344,共5页Hebei Medical Journal

摘　　要：目的分析充气式保温毯联合多模式体温干预在非小细胞肺癌手术中的应用效果。方法选取宿迁市第一人民医院(江苏省人民医院宿迁分院)2021年3月至2023年3月收治的135例非小细胞肺癌患者为研究对象,按照随机分组法分为充气式保温毯组45例,多模式体温干预组42例,联合组48例,充气式保温毯组使用充气式保温毯保温干预,多模式体温干预组进行多模式体温干预,联合组采用充气式保温毯联合多模式体温干预,检测3组患者循环代谢指标、生命体征、凝血功能、应激反应指标、炎性因子、并发症发生情况、手术相关指标。结果与术前比较,充气式保温毯组、多模式体温干预组术后30 min体温下降,PETCO_(2)、心率、收缩压、PT、APTT、TT升高(P<0.05);与术前比较,联合组术后30 min体温、PET CO_(2)、心率、收缩压、PT、APTT、TT变化较小,差异无统计学意义(P>0.05);与充气式保温毯组、多模式体温干预组术后30 min比较,联合组患者体温较高,PETCO_(2)、心率、收缩压、PT、APTT、TT较低(P<0.05)。与术前比较,3组患者术后30 min Cor、NE、IL-6、TNF-α升高;与充气式保温毯组、多模式体温干预组术后30 min比较,联合组患者Cor、NE、IL-6、TNF-α较低。与充气式保温毯组、多模式体温干预组比较,联合组并发症发生情况较少,术后苏醒时间、术中出血量、手术时间、术后拔管时间较短(P<0.05)。结论在非小细胞肺癌术中采用充气式保温毯联合多模式体温干预,可使患者术后循环代谢指标、凝血功能保持正常,并减少氧化应激反应的发生,降低手术并发症发生率,临床使用效果较好。Objective To analyze the application effect of an inflatable thermal blanket combined with multimodal body temperature intervention in non-small cell lung cancer(NSCLC)surgery.Methods A total of 135 NSCLC patients admitted to the Suqian First Hospital(Suqian Branch,Jiangsu Province Hospital)from March 2021 to March 2023 were selected as the research subjects.They were randomly divided into the inflatable thermal blanket group(n=45),multimodal body temperature intervention group(n=42)and combination group(n=48).An inflatable thermal blanket was given to patients of inflatable thermal blanket group,and multimodal body temperature intervention was given to those of multimodal body temperature intervention group.Their combination was applied to patients of combination group.Circulating metabolism indicators,vital signs,coagulation function,stress response indicators,inflammation factors,complications,and operation-related indicators were compared.Results Compared with those before surgery,the body temperature of the inflatable thermal blanket group and the multimodal body temperature intervention group decreased 30min after surgery,and the partial pressure of end-tidal CO_(2)(PetCO_(2)),heart rate,systolic blood pressure,activated partial thromboplastin time(APTT),prothrombin time(PT),and thrombin time(TT)significantly increased(P<0.05).Compared with those before surgery,the changes in the body temperature,PetCO_(2),heart rate,systolic blood pressure,PT,APTT,and TT in the combination group at 30min after surgery were small without significant differences(P>0.05).Compared with those of the inflatable thermal blanket group and the multimodal body temperature intervention group at 30min after operation,the body temperature of patients in the combination group was significantly higher,and the PetCO_(2),heart rate,systolic blood pressure,PT,APTT,and TT were significantly lower(P<0.05).Compared with those before surgery,the levels of cortisol(COR),norepinephrine(NE),interleukin-6(IL-6),and tumor necrosis factor alpha(TNF-�

关 键 词：非小细胞肺癌 充气式保温毯 多模式体温干预 低体温 氧化应激 凝血功能 

分 类 号：R734.2[医药卫生—肿瘤]