脉冲CO_(2)激光结合牙周基础治疗对青春期龈炎前瞻性半口自身对照研究  

Pulsed CO_(2) lasers combined with basic periodontal therapy for adolescent gingivitis:a prospective split-mouth self-controlled study

作　　者：薛妹 张文平 王树军 周冰 刘静 潘福勤[2] XUE Mei;ZHANG Wenping;WANG Shujun(Cangzhou Stomatology Hospital Co.,Ltd.,Hebei,Cangzhou 061000,China)

机构地区：[1]河北省沧州口腔医院有限公司,061000 [2]沧州医学高等专科学校

出　　处：《河北医药》2024年第3期363-366,371,共5页Hebei Medical Journal

基　　金：沧州市重点研发计划指导项目(编号:213106052)。

摘　　要：目的基于半口自身对照研究观察脉冲CO_(2)激光结合牙周基础治疗对青春期龈炎的疗效。方法选择200例符合标准的青春期龈炎患者,采用左右半口自身对照研究,一侧行牙周基础治疗,为对照组;另一侧行脉冲CO_(2)激光结合牙周基础治疗,为治疗组。对比分析2组患者牙龈红肿、出血好转时间,治疗后7 d和6周时探诊深度(PD)>3 mm的位点数、探诊出血(BOP)阳性位点数、BOP百分率、牙龈指数(GI)、出血指数(BI)、菌斑指数(PLI)的变化以及龈沟液白细胞介素1β(IL-1β)、C-反应蛋白(CRP)、前列腺素E_(2)(PGE_(2))、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平的改变。结果治疗组牙龈红肿、出血好转时间均早于对照组(均P<0.05)。治疗后7 d和6周时,2组PD>3 mm的位点数、BOP阳性位点数和BOP百分率均降低(P<0.05),且治疗组较对照组更低(P<0.05)。治疗后7 d和6周时,2组PLI、GI、BI均降低(均P<0.05),且治疗组PLI、GI、BI均低于对照组(P<0.05)。治疗后6周时2组龈沟液IL-1β、CRP、PGE_(2)、TNF-α、IL-6水平均下降(均P<0.05),且治疗组低于对照组(均P<0.05)。结论相对于单纯牙周基础治疗,脉冲CO_(2)激光结合牙周基础治疗对青春期龈炎的临床疗效更佳,且能较快改善患者临床症状,降低局部炎性反应。Objective To observe the efficacy of pulsed CO_(2) lasers combined with basic periodontal therapy on adolescent gingivitis via conducting a split-mouth self-controlled study.Methods A total of 200 adolescent gingivitis patients were selected as the control group.The left and right mouth were self-controlled,with one side treated with basic periodontal therapy(control group),and the other side treated with pulsed CO_(2) lasers combined with basic periodontal therapy(treatment group).The improvement time of gingival swelling and bleeding were compared and analyzed between the two groups.The number of probing depth(PD)>3mm,the number of positive sites of bleeding on probing(BOP),the percentage of BOP,gingival index(GI),bleeding index(BI),plaque index(PLI)and interleukin-1β(IL-1β),C-reactive protein(CRP),prostaglandin E-2(PGE-2),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)levels in gingival crevicular fluid at 7 days and 6 weeks after treatment were compared.Results Gingival swelling and bleeding in the treatment group was significantly improved earlier than those in the control group(both P<0.05).After 7 days of treatment and 6 weeks of treatment,the site number of PD>3mm,the positive site number of BOP and the percentage of BOP were significantly reduced in both groups,which were significantly lower in the treatment group than in control group(P<0.05).After 7 days of treatment and 6 weeks of treatment,PLI,GI and BI in both groups were significantly reduced,which were significantly lower in the treatment group than in the control group(P<0.05).After 6 weeks of treatment,IL-1β,CRP,PGE-2,TNF-αand IL-6 levels in the gingival crevicular fluid were significantly reduced in both groups,which were significantly lower in the treatment group than in the control group(P<0.05).Conclusion Compared with the monotherapy of basic periodontal treatment,its combination with pulsed CO_(2) lasers has a better clinical efficacy on adolescent gingivitis,which can improve the clinical symptoms of patients faster and reduce lo

关 键 词：牙龈炎 青春期 脉冲CO_(2)激光治疗 

分 类 号：R781.41[医药卫生—口腔医学]