营养支持疗法对老年原发性支气管肺癌患者的效果及对化疗期间生活质量的影响  

Application effect of nutritional support therapy on elderly patients with primary bronchogenic carcinomas and its impact on their quality of life during chemotherapy

作　　者：王玲 朱丽[1] 李茸 李潇 WANG Ling;ZHU Li;LI Rong(Department of Radiotherapy,the First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi,Xi’an 710061,China)

机构地区：[1]西安交通大学第一附属医院放疗科,西安市710061

出　　处：《河北医药》2024年第3期414-417,共4页Hebei Medical Journal

摘　　要：目的探讨老年原发性支气管肺癌患者中应用营养支持疗法的效果及对患者化疗期间生活质量的影响。方法纳入西安交通大学第一附属医院放疗科2020年1月至2021年6月收治的老年原发性支气管肺癌患者86例为研究对象,随机分2组,每组43例。对照组采用常规干预,研究组采用营养支持疗法进行干预,比较2组的营养状况、化疗期间生活质量、免疫功能、不良反应和干预满意度。结果研究组干预后的总蛋白、血清蛋白、血红蛋白水平分别为(53.88±2.39)g/L、(32.43±1.79)g/L、(9.49±1.36)g/L,对照组干预后的总蛋白、血清蛋白、血红蛋白水平分别为(46.78±2.05)g/L、(29.19±1.53)g/L、(8.15±1.32)g/L,2组干预后的总蛋白、血清蛋白、血红蛋白水平均高于干预前,且研究组高于对照组(P<0.05)。研究组化疗期间特异性生活质量量表(QLQ-LC13)评分高于对照组(P<0.05)。研究组免疫球蛋白(IgG、IgA、IgM)水平和总淋巴细胞计数(TLC)水平分别为(8.13±0.66)g/L、(2.97±0.48)g/L、(1.43±0.17)g/L和(1.05±0.11)×10^(9)/L,对照组免疫球蛋白(IgG、IgA、IgM)水平和TLC水平分别为(7.31±0.65)g/L、(2.02±0.21)g/L、(1.12±0.11)g/L和(0.71±0.13)×10^(9)/L,研究组免疫指标水平高于对照组(P<0.05)。研究组不良反应发生率为6.98%,低于对照组的23.26%(P<0.05)。研究组干预满意度为95.35%,高于对照组的74.42%(P<0.05)。结论老年原发性支气管肺癌患者中应用营养支持疗法,可改善患者的营养状况,降低不良反应,提高患者的免疫功能、生活质量和满意度。Objective To explore the effectiveness of nutritional support therapy on elderly patients with primary bronchogenic carcinomas and its impact on their quality of life during chemotherapy.Methods A total of 86 elderly patients with primary bronchogenic carcinomas admitted to Department of Radiotherapy,the First Affiliated Hospital of Xi’an Jiaotong University from January 2020 to June 2021 were included as the study subjects.They were randomly divided into the research group and control group,with 43 cases in each group.Routine intervention was applied to patients of control group,and nutritional support therapy was given to those of the research group.The nutritional status,quality of life during chemotherapy,immune function,adverse events,and intervention satisfaction between the two groups were compared.Results The total protein,serum protein,and hemoglobin levels in the research group after intervention were(53.88±2.39)g/L,(32.43±1.79)g/L,and(9.49±1.36)g/L,respectively,which,in the control group after intervention were(46.78±2.05)g/L,(29.19±1.53)g/L,and(8.15±1.32)g/L,respectively.The total protein,serum protein,and hemoglobin levels in both groups after intervention were significantly higher than those before intervention,which were significantly higher in the research group than those of control group(P<0.05).The Quality of Life Questionnaire-Lung Cancer 13(QLQ-LC13)score during chemotherapy in the research group was significantly higher than that of the control group(P<0.05).The levels of immunoglobulin G,A and M(IgG,IgA,IgM)and total lymphocyte count(TLC)in the research group were(8.13±0.66)g/L,(2.97±0.48)g/L,(1.43±0.17)g/L,and(1.05±0.11)×10^(9)/L,respectively,which,in the control group were(7.31±0.65)g/L,(2.02±0.21)g/L,(1.12±0.11)g/L,and(0.71±0.13)×10^(9)/L,respectively.Immune index levels of the research group were significantly higher than those of the control group(P<0.05).The incidence of adverse events in the research group was significantly lower than that of the control group(6.98%

关 键 词：营养状况 原发性支气管肺癌 免疫功能 营养支持疗法 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]