γ-谷氨酰转移酶1的功能及相关研究进展  

Functional and related research progress ofγ-glutamyltransferase 1

作　　者：公海凤 张冰 纪洪[1,3] Gong Haifeng;Zhang Bing;Ji Hong(Department of Pathology,Affiliated Hospital to Binzhou Medical University,Binzhou 256603,China;Department of Urology,Qilu Hospital of Shandong University(Qingdao),Qingdao 266035,China;Department of Pathology,Qilu Hospital of Shandong University(Qingdao),Qingdao 266035,China)

机构地区：[1]滨州医学院附属医院病理科,滨州256603 [2]山东大学齐鲁医院(青岛)泌尿外科,青岛266035 [3]山东大学齐鲁医院(青岛)病理科,青岛266035

出　　处：《中国医师杂志》2024年第2期311-313,共3页Journal of Chinese Physician

基　　金：山东省自然科学基金(ZR2020MC068)。

摘　　要：γ-谷氨酰转移酶1(GGT1)参与调节氧化还原、细胞增殖、肿瘤转移及耐药等过程,在前列腺癌、透明细胞肾细胞癌等多种肿瘤中异常表达。本文总结了GGT1在多种疾病中的表达情况及作用,为进一步探索GGT1相关疾病的治疗策略提供新思路。Gamma glutamyltransferase 1(GGT1)is involved in regulating processes such as redox,cell proliferation,tumor metastasis,and drug resistance,and is abnormally expressed in various tumors such as prostate cancer and clear cell renal cell carcinoma.This article summarizes the expression and role of GGT1 in various diseases,providing new ideas for further exploration of treatment strategies for GGT1 related diseases.

关 键 词：γ-谷氨酰转移酶1 肿瘤转移 抗药性 肿瘤 

分 类 号：R363[医药卫生—病理学]