周围型肝内胆管细胞癌在立体定向放疗两种调强放疗方式下靶体积大小对剂量梯度变化的差异性研究  

Differential Study on the Effect of Target Volume Size on Dose Gradient Changes in Peripheral Intrahepatic Cholan-giocarcinoma under Two Intensity-modulated Radiotherapy Methods under Stereotactic Radiotherapy

作　　者：何成[1] He Cheng(Department of Radiotherapy,Qinzhou First People's Hospital,Qinzhou 535000,Guangxi,China)

机构地区：[1]钦州市第一人民医院放疗科,广西壮族自治区钦州535000

出　　处：《中外医药研究》2023年第33期46-48,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨周围型肝内胆管细胞癌(IHPCC)在立体定向放疗(SBRT)两种调强放疗方式下靶体积大小对剂量梯度变化的影响。方法:选取2020年1月—2023年6月钦州市第一人民医院放疗科收治的IHPCC患者80例为研究对象,根据不同调强放疗方式划分为研究组和对照组,各40例。对照组采用动态调强放射治疗(IMRT),研究组采用容积弧形调强放射治疗(VMAT)。比较两组剂量学参数、放疗参数、危及器官和部位受照剂量。结果:研究组剂量学参数靶区最大剂量、靶区适形指数高于对照组,靶区平均剂量、靶区最小剂量及靶区均匀指数低于对照组,差异有统计学意义(P<0.05);研究组放疗照射时间短于对照组,子野数、总子野跳数多于对照组,差异有统计学意义(P<0.05);研究组脊髓、左肾、右肾及胃受照剂量均低于对照组,差异有统计学意义(P<0.05)。结论:对于IHPCC患者,VMAT放疗的靶体积覆盖率优于IMRT,剂量分布更均匀。Objective:To investigate the effect of target size on the dose gradient of peripheral intrahepatic cholangiocarcinoma(IHPCC)under two intensive-modulated radiotherapy modalities of stereotactic radiotherapy(SBRT).Methods:A total of eighty IHPCC patients admitted to the department of radiotherapy of Qinzhou First People's Hospital from January 2020 to June 2023 were selected as the study objects,and were divided into study group and control group according to different intensity modulated radiotherapy methods,with forty cases in each group.The control group received dynamic intensity modulated radiation therapy(IMRT),and the study group received volumetric arc intensity modulated radiation therapy(VMAT).The dosimetry parameters,ra-diotherapy parameters and radiation dose to the organs at risk were compared between the two groups.Results:The maximum dose and conformance index of dosimetric parameters in the study group were higher than those in the control group,the average dose,minimum dose and evenness index of target were lower than those of control group,and the difference was statistically significant(P<0.05);The duration of radiotherapy in the study group was shorter than that in the control group,and the number of subfield and total subfield hops were higher than that in the control group,the difference was statistically significant(P<0.05);The doses of spinal cord,left kidney,right kidney and stomach in the study group were lower than those in the control group,and the differenc-es were statistically significant(P<0.05).Conclusion:For IHPCC patients,VMAT radiotherapy has better target volume coverage than IMRT,and dose distribution is more uniform.

关 键 词：周围型肝内胆管细胞癌 立体定向放疗 调强放疗 靶体积 放疗剂量 

分 类 号：R73[医药卫生—肿瘤]